1425-63-4

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Diamino-6,7-dimethylpteridine serves as an intermediate in the synthesis of folic acid and its derivatives, which are essential for various biological processes, including DNA synthesis and repair.
Used in Anticancer Applications:
2,4-DIAMINO-6,7-DIMETHYLPTERIDINE is used in the production of several antineoplastic agents, which are drugs that inhibit the growth and proliferation of cancer cells. It is also being investigated for its potential as a direct anticancer agent, with ongoing research to understand its mechanism of action and effectiveness against various types of cancer.
Used in Biological Research:
2,4-Diamino-6,7-dimethylpteridine has been studied for its role in various biological processes, including its potential as a fluorescent probe for detecting oxidative stress in cells. Oxidative stress is a critical factor in many diseases, and the ability to detect and measure it can aid in the development of therapeutic strategies to mitigate its effects.

InChI:InChI=1/C8H10N6/c1-3-4(2)12-7-5(11-3)6(9)13-8(10)14-7/h1-2H3,(H4,9,10,12,13,14)

Upstream product

• 1004-74-6 2,4,5,6-tetraaminopyrimidine 
• 431-03-8 dimethylglyoxal 
• 5392-28-9 2,4,5,6-tetraaminopyrimidine sulfate 
• 54972-21-3 1-tosyl-4,5-dimethylimidazolin-2-one 
• 593-85-1 diguanidine carbonate 
• 606964-90-3 4-(benzylsulfanyl)-6,7-dimethyl-2-pteridinamine 

Downstream Products

• 5774-32-3 6,7-dimethyllumazine 
• 611-55-2 6,7-Dimethylpterin 

Relevant academic research and scientific papers

A prototype solid phase synthesis of pteridines and related heterocyclic compounds

The development of a versatile solid phase synthesis of bicyclic polyaza heterocycles including pteridines, purines, and deazapurines is described. The strategy comprises the linking of a pre-formed pyrimidine through a thioether at the 2 or 4 position to a polystyrene resin, the cyclisation of the second ring, and the direct or oxidative cleavage of the product from the resin by nucleophilic substitution. This provides not only for substituent variation in the second ring, but also for variation at the site of cleavage. Limitations in the scope of the methodology are set by the intrinsic reactivity of pyrimidinyl 2- or 4-thioethers which, whilst undergoing ready nitration at C5, are surprisingly difficult to alkylate and acylate.

Antiamnesic use of pteridine derivatives

Pteridines of general formula (I): STR1 in which Y and Z, which can be identical or different, are hydrogen, OH or NH2, and X1 and X2, which can be identical or different, are hydrogen, OH, C1 -C4 alkyl, phenyl, hydroxymethyl or carboxyl, for the preparation of pharmaceutical compositions for treating cognitive pathologies characterized by memory and vigilance disturbances, such as senile dementia of Alzheimer type, multiinfarctual dementia, metabolic encephalopathies, Korsakoff's syndrome, and the consequences of the abuse of certain therapies such as anxiolytic and neuroleptic.