5774-32-3

Basic information

• Product Name: 6,7-Dimethylpteridine-2,4(1H,3H)-dione
• Synonyms: 2-Hydroxy-6,7-dimethyl-3,4-dihydropteridine-4-one;6,7-Dimethyl-2,4(1H,3H)-pteridinedione;6,7-Dimethyllumazine;6,7-Dimethylpteridine-2,4(1H,3H)-dione
• CAS NO: 5774-32-3
• Molecular Formula: C₈H₈N₄O₂
• Molecular Weight: 192.1747
• Mol File: 5774-32-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.369g/cm³
• Refractive Index: 1.579
• CAS DataBase Reference: 6,7-Dimethylpteridine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Dimethylpteridine-2,4(1H,3H)-dione(5774-32-3)
• EPA Substance Registry System: 6,7-Dimethylpteridine-2,4(1H,3H)-dione(5774-32-3)

Safety Data

• Hazardous Substances Data: 5774-32-3(Hazardous Substances Data)

Usage

General Description

6,7-Dimethylpteridine-2,4(1H,3H)-dione is a chemical compound with the molecular formula C8H8N4O2. It is a pteridine derivative, a family of compounds that are essential for the synthesis of several important biomolecules in living organisms. 6,7-Dimethylpteridine-2,4(1H,3H)-dione has potential pharmaceutical and industrial applications due to its unique chemical properties. It is known to have antioxidant and antiviral properties, and is being studied for its potential role in the treatment of various diseases. Additionally, it is used in the production of dyes, pigments, and other industrial chemicals. 6,7-Dimethylpteridine-2,4(1H,3H)-dione has potential for a wide range of applications due to its diverse chemical properties and potential biological activity.

InChI:InChI=1/C8H8N4O2/c1-3-4(2)10-6-5(9-3)7(13)12-8(14)11-6/h1-2H3,(H2,10,11,12,13,14)

Upstream product

• 3240-72-0 5,6-diaminouracil 
• 431-03-8 dimethylglyoxal 
• 1425-63-4 6,7-dimethyl-2,4-pteridine-2,4-diamine 
• 500692-39-7 2,4-dichloro-6,7-dimethylpteridine 
• 42965-55-9 5,6-diaminouracil sulfate 
• 21892-66-0 8-Isopropyl-6,7-dimethyl-lumazin 
• 81964-61-6 6,7-Dimethyl-8-D-ribityl-lumazin 
• 13300-17-9 8-(2-Hydroxyethyl)-6,7-dimethyl-lumazin 
• 7647-01-0 hydrogenchloride 
• 606964-89-0 2-(benzylsulfanyl)-6,7-dimethyl-4(3H)-pteridinone 
• 42965-55-9 5,6-diamino-2,4-dihydroxypyrimidine sulfate 
• 1004-40-6 6-amino-2-thioxo-1,2-dihydro-4(3H)-pyrimidinone 

Downstream Products

• 6294-71-9 3-amino-5,6-dimethyl-pyrazine-2-carboxylic acid 
• 50256-07-0 1-[O³,O⁵-bis-(4-methyl-benzoyl)-β-D-erythro-2-deoxy-pentofuranosyl]-6,7-dimethyl-1H-pteridine-2,4-dione 
• 6298-34-6 sulfanilic acid-(5,6-dimethyl-pyrazin-2-ylamide) 
• 6294-70-8 2-amino-5,6-dimethylpyrazine 
• 159228-04-3 1-(2,3-dideoxy-3-iodo-5-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6,7-dimethyllumazine 
• 159228-03-2 1-(2-deoxy-5-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6,7-dimethyllumazine 
• 159228-05-4 1-(2,3-dideoxy-5-O-p-toluoyl-β-D-glycero-pentofuranosyl)-6,7-dimethyllumazine 

Relevant articles and documents

A traceless solid-phase synthesis of pteridines

The linking of pyrimidines to polystyrene supports via either a 2- or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.

Evaluation of liquid chromatographic behavior of lumazinic derivatives, from α-dicarbonyl compounds, in different c18 columns: Application to wine samples using a fused-core column and fluorescence detection

Several C18 columns, packed with totally porous particles of different sizes and shell thicknesses, have been compared for simultaneous determination of α-dicarbonyl compounds, previous derivatization to lumazinic derivatives. Chromatographic conditions for the separation have been optimized for each column, and chromatographic parameters have been calculated and exhaustively compared. A core-shell C18 column provided the best results, and a HPLC method with fluorimetric detection has been proposed. The developed method has been validated in terms of linearity, precision, and sensitivity. Detection and quantification limits obtained were comprised between 0.02 and 0.30 and 0.07 and 1.0 ng mL-1, respectively, while RSD values obtained were lower than 6% and 5% in intraday and interday repeatability studies, respectively. The method has been applied to analysis of the α-dicarbonyl compounds in different types of wines. The higher levels of the total α-dicarbonyl compounds were found in sweet wines and the lower levels in white wines.

Pteridine nucleotide analogs as fluorescent DNA probes

The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotidcs. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.