14250-75-0

Basic information

• Product Name: 2,2-DIMETHYLNONANOIC ACID
• Synonyms: RARECHEM AH CK 0092;2,2-DIMETHYLNONANOIC ACID;2,2-DIMETHYLNONANOIC ACID >98%
• CAS NO: 14250-75-0
• Molecular Formula: C₁₁H₂₂O₂
• Molecular Weight: 186.29
• Mol File: 14250-75-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 130-132°C
• Flash Point: 129.6 °C
• Appearance: /
• Density: 0.8978 (rough estimate)
• Vapor Pressure: 0.000815mmHg at 25°C
• Refractive Index: 1.4205 (estimate)
• CAS DataBase Reference: 2,2-DIMETHYLNONANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYLNONANOIC ACID(14250-75-0)
• EPA Substance Registry System: 2,2-DIMETHYLNONANOIC ACID(14250-75-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 14250-75-0(Hazardous Substances Data)

Usage

General Description

2,2-Dimethylnonanoic acid is a branched chain carboxylic acid with the chemical formula C11H22O2. It is a colorless liquid at room temperature and is insoluble in water, but soluble in organic solvents. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It can also be utilized as a corrosion inhibitor and as a chemical intermediate in the production of esters, ethers, and other organic compounds. Additionally, 2,2-Dimethylnonanoic acid is also used as a fragrance ingredient in personal care and cleaning products.

InChI:InChI=1/C11H22O2/c1-4-5-6-7-8-9-11(2,3)10(12)13/h4-9H2,1-3H3,(H,12,13)

Upstream product

• 872-05-9 1-Decene 
• 201230-82-2 carbon monoxide 
• 112-30-1 1-Decanol 
• 629-04-9 1-Bromoheptane 
• 79-31-2 isobutyric Acid 
• 64-18-6 formic acid 
• 10297-57-1 2-methylnonan-2-ol 

Downstream Products

• 140112-68-1 2,2-Dimethyl-nonanoic acid (2,4,6-trimethoxy-phenyl)-amide 

Relevant articles and documents

A new rhodium catalyst: Formation of [Rh(CO)4]+ in concentrated sulfuric acid and its application to carbonylation of olefins

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Palladium(I) Carbonyl Cation-Catalyzed Carbonylation of Olefins and Alcohols in Concentrated Sulfuric Acid

A new palladium catalyst was found to exhibit high catalytic activity for carbonylation of olefins and alcohols. cyclo-Bis(μ-carbonyl)dipalladium(I) cation (1) with bridging CO ligands is formed by reductive carbonylation of palladium sulfate, PdSO4, in concentrated H2SO4. When an olefin or alcohol is added, complex 1 changes to a new complex (2) with terminal CO ligands, and tertiary carboxylic acids are obtained in high yields at room temperature and atmospheric pressure of CO. IR and 13C NMR studies suggest that complex 2 may be tentatively formulated to be [Pd2(CO)2]2+, in which the terminal CO ligands are chemically equivalent. Complex 1 is a catalyst precursor, and complex 2 functions as an active species for the carbonylation of olefins and alcohols. The catalytic behavior of the palladium carbonyl catalyst supports the recently proposed reaction mechanism involving an olefin-metal-CO complex as an intermediate for the catalytic carbonylation of olefins and alcohols in strongly acidic solution.

Inhibitors of Acyl-CoA:cholesterol acyltransferase. I. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents

A series of fatty acid anilides was prepared, and compounds were tested for their ability to inhibit the enzyme acyl-CoA:cholesterol acyltransferase (ACAT) in vitro and to lower plasma total cholesterol and elevate high- density lipoprotein cholesterol in cholesterol-fed rats in vivo. The compounds reported were found to fall into two subclasses with different anilide SAR. For nonbranched acyl analogues, inhibitory potency was found to be optimal with bulky 2,6-dialkyl substitution. For α-substituted acyl analogues, there was little dependence of in vitro potency on anilide substitution and 2,4,6-trimethoxy was uniquely preferred. Most of the potent inhibitors (IC50 50 nM) were found to produce significant reductions in plasma total cholesterol in cholesterol-fed rats. Additionally, in vivo activity could be improved significantly by the introduction of α,α- disubstitution into the fatty acid portion of the molecule. A narrow group of α,α-disubstituted trimethoxyanilides, exemplified by 2,2-dimethyl-N-(2,4,6- trimethoxyphenyl)dodecanamide (39), was found to not only lower plasma total cholesterol (-60%) in cholesterol-fed rats but also elevate levels of high- density lipoprotein cholesterol (+94%) in this model at the screening dose of 0.05% in the diet (ca. 50 mg/kg).