142501-48-2

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 142501-53-9 (1RS,2SR,3RS)-4-(4-benzyloxy-3,5-dimethoxyphenyl)-2,3-dimethyl-1-(3,4,5-trimethoxyphenyl)butyl acetate 
• 142501-53-9 (1RS,2RS,3SR)-4-(4-benzyloxy-3,5-dimethoxyphenyl)-2,3-dimethyl-1-(3,4,5-trimethoxyphenyl)butyl acetate 
• 142501-51-7 (2RS,3SR)-4-(4-benzyloxy-3,5-dimethoxyphenyl)-2,3-dimethyl-1-(3,4,5-trimethoxyphenyl)butan-1-one 
• 142501-51-7 (2RS,3RS)-4-(4-benzyloxy-3,5-dimethoxyphenyl)-2,3-dimethyl-1-(3,4,5-trimethoxyphenyl)butan-1-one 
• 142501-45-9 (2R,3S)-4-(4-Benzyloxy-3,5-dimethoxy-phenyl)-2,3-dimethyl-1-(3,4,5-trimethoxy-phenyl)-butan-1-ol 
• 142501-56-2 Acetic acid (1R,2R,3S,4R)-5,6,7-trimethoxy-4-(5-methoxy-3,4-dioxo-cyclohexa-1,5-dienyl)-2,3-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl ester 
• 142501-54-0 (1RS,2RS,3SR)-4-(4-hydroxy-3,5-dimethoxyphenyl)-2,3-dimethyl-1-(3,4,5-trimethoxyphenyl)butyl acetate 
• 142501-47-1 (2RS,3SR)-4-(4-hydroxy-3,5-dimethoxyphenyl)-2,3-dimethyl-1-(3,4,5-trimethoxyphenyl)butan-1-one 
• 205366-80-9 (1R,2R)-1-(4-Methoxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol 
• 205366-87-6 (1S,2S)-1-(4-Methoxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol 

Relevant academic research and scientific papers

Cyanosilylation of aldehydes and ketones catalyzed by nanocrystalline magnesium oxide

Cyanosilylation of various aldehydes and ketones with TMSCN proceeded smoothly under mild conditions to give the corresponding cyanohydrin trimethylsilyl ethers in the presence of nanocrystalline magnesium oxide. The cyanohydrin trimethylsilyl ethers of aldehydes produced cyanohydrins in good to high yields on treatment with 2 N HCl. 29Si NMR spectral evidence proved that the reaction proceeds through the hypervalent silicate species by coordination to O2-/O- (Lewis basic site) of nanocrystalline magnesium oxide. Copyright Taylor & Francis Group, LLC.

Three Coordinated Organoaluminum Cation for Rapid and Selective Cyanosilylation of Carbonyls under Solvent-Free Conditions

The well-defined three coordinated electronically unsaturated cationic organoaluminum complex [({(2,6-iPr2C6H3N)P(Ph2)}2N)AlMe]+[MeB(C6F5)3]? (1), has been utilized to catalyze the cyanosilylation of aldehydes and ketones under mild and solvent-free conditions. Moreover, catalyst 1 showed high chemoselective cyanosilylation of aldehydes over ketones, nitriles and olefins. The multinuclear NMR investigations revealed that cyanosilylation proceeds via Lewis adduct formation between 1 and TMSCN thereby activating TMSCN (Si-CN bond) followed by nucleophilic attack of the carbonyl oxygen at the Si center of the activated silane and formation of the product.

Efficient, rapid and solvent-free cyanosilylation of aldehydes and ketones catalyzed by SbCl3

Antimony trichloride(SbCl3) was demonstrated to be an effective catalyst for the cyanosilylation of a wide variety of carbonyl compounds under solvent-free conditions. The reactions proceeded smoothly at room temperature to afford the correspon

Combretoxazolones: Synthesis, cytotoxicity and antitumor activity

Two series of combretoxazolones including 3,4-diaryloxazolones (6) and 4,5-diaryloxazolones (7) were synthesized and evaluated for cytotoxicity and antitumor activity. Both series showed strong cytotoxicities against a variety of tumor cell lines. Compound 6g exhibited a significant antitumor activity in BDF1 mice bearing B16 murine melanoma cells with inhibition rates of 67 and 61% at 100 and 30 mg/kg/day, respectively.

Synthesis of conformationary restricted combretastatins

A series of conformationary restricted heterocyclic combretastatin analogs have been synthesized and their inhibitory activity of microtubule assembly was evaluated. (45,55)-4-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3-dioxolane showed moderate anti

Process for preparing a naphthalene derivative and a synthetic intermediate thereof

A novel process for preparing a naphthalene derivative of the formula: STR1 wherein R1 and R2 are a lower alkoxycarbonyl group or both may combine to form a group of the formula STR2 one of R3 and R4 is hydrogen

Intramolecular Oxidative Coupling of Aromatic Compounds. I Oxidation of Diphenolic Substrates

The synthesis of (2RS,3SR)-1-(3,5-dihydroxy-4-methoxyphenyl)-(4-hydroxy-3,5-dimethoxyphenyl)2,3-dimethylbutan-1-one (26) is described.Diphenolic oxidative coupling of (26) did not produce a eupodienone-type product.An aryltetralin derivative was formed in

Enzymatic Preparation of Optically Active Cyanohydrin Acetates

A series of cyanohydrin acetates (1)-(47) of widely varying structures, potential chiral building blocks for numerous synthetic applications, has been prepared in good chemical and often high optical yields by enzymatic hydrolysis of their racemic acetates in the presence of an ester hydrolase from Pseudomonas sp.