91134-18-8

Usage

Uses

Used in Pharmaceutical Research and Development:
(3,4,5-trimethoxyphenyl)glycolonitrile is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Organic Synthesis:
(3,4,5-trimethoxyphenyl)glycolonitrile is used as a building block in the synthesis of complex organic molecules. Its versatility in chemical reactions makes it a valuable component in the creation of new organic compounds.
Used in Organic Electronics:
(3,4,5-trimethoxyphenyl)glycolonitrile may have potential applications in the field of organic electronics due to its electronic properties. It could be used in the development of new electronic materials and devices.
Used in Materials Science:
(3,4,5-trimethoxyphenyl)glycolonitrile may also be utilized in materials science for the development of new materials with unique properties. Its potential use in this field is still under investigation.
Used in Drug Discovery and Medicinal Chemistry:
(3,4,5-trimethoxyphenyl)glycolonitrile may exhibit various biological activities, making it a subject of interest in the study of drug discovery and medicinal chemistry. Its potential as a lead compound for new drug development is being explored.
Safety Precautions:
As with any chemical compound, proper handling and safety precautions should be taken when working with (3,4,5-trimethoxyphenyl)glycolonitrile to ensure the safety of researchers and the environment.

InChI:InChI=1/C11H13NO4/c1-14-9-4-7(8(13)6-12)5-10(15-2)11(9)16-3/h4-5,8,13H,1-3H3

Upstream product

• 142501-48-2 (3,4,5-trimethoxyphenyl)(trimethylsilyloxy)acetonitrile 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 773837-37-9 sodium cyanide 
• 151-50-8 potassium cyanide 

Downstream Products

• 54-04-6 mescaline 
• 3866-01-1 5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-ylamine 
• 91958-61-1 acetoxy-3,4,5-trimethoxyphenylacetonitrile 
• 13079-18-0 1-(1-hydroxy-2-aminoethyl)-3,4,5-trimethoxy benzene 
• 951-82-6 3,4,5-trimethoxyphenyl acetic acid 

Relevant academic research and scientific papers

(5-aryl-1,2,4-oxadiazole-3-yl)(3,4,5-trimethoxyphenyl)-methanol, -ketone and -ketoxime compounds and application thereof

The invention belongs to the technical field of medicines, relates to (5-aryl-1,2,4-oxadiazole-3-yl)(3,4,5-trimethoxyphenyl)-methanol, -ketone and -ketoxime compounds and application thereof and in particular relates to the compounds and application thereof to an aspect of preparing anti-tumor medicines by taking the compounds as a tumor cell proliferation inhibitor. The compounds provided by the invention have a general molecular formula shown as the description, wherein X is selected from CH-OH, C=O and C=N-OH; R is selected from hydrogen, hydroxyl, amino, a halogen atom, nitryl, C1 to C6 alkyl, C1 to C6 alkyloxy and C1 to C6 alkylamino. The compounds provided by the invention have a relatively good effect on treating tumor diseases and have a relatively good application prospect in preparation of the anti-tumor medicines.

Microwave-assisted synthesis, molecular docking and antiproliferative activity of (3/5-aryl-1,2,4-oxadiazole-5/3-yl)(3,4,5-trimethoxyphenyl)methanone oxime derivatives

A series of (3/5-aryl-1,2,4-oxadiazole-5/3-yl)(3,4,5-trimethoxyphenyl)methanone oxime derivatives were synthesized via a rapid and facile microwave-assisted synthesis method of building a 1,2,4-oxadiazole skeleton using mandelic acid as the starting material. Twenty-four target compounds were evaluated for their in vitro antiproliferative activities against three human cancer cell lines (SGC-7901, A549 and HT-1080). Among them, 16b exhibited the highest potency against different tumour cell lines, especially the A549 cell line (IC50 = 87 nM). Structure-activity relationship (SAR) studies revealed that the aryl substituent at the C-5 position on the 1,2,4-oxadiazole ring is superior to that at the C-3 position. An oxime as a connector can obviously increase the potency, contrary to that in SMART derivatives. Moreover, 16b significantly induced a cell cycle arrest in the G2/M phase and caused microtubule destabilization. Molecular docking studies provided a theoretical binding mode of 16b at the colchicine site in the tubulin dimer. Our work laid the foundation for further structure-guided design of novel tubulin polymerization inhibitors.

Cyanosilylation of aldehydes and ketones catalyzed by nanocrystalline magnesium oxide

Cyanosilylation of various aldehydes and ketones with TMSCN proceeded smoothly under mild conditions to give the corresponding cyanohydrin trimethylsilyl ethers in the presence of nanocrystalline magnesium oxide. The cyanohydrin trimethylsilyl ethers of aldehydes produced cyanohydrins in good to high yields on treatment with 2 N HCl. 29Si NMR spectral evidence proved that the reaction proceeds through the hypervalent silicate species by coordination to O2-/O- (Lewis basic site) of nanocrystalline magnesium oxide. Copyright Taylor & Francis Group, LLC.

A new (R)-hydroxynitrile lyase from Prunus mume: Asymmetric synthesis of cyanohydrins

A new hydroxynitrile lyase (HNL) was isolated from the seed of Japanese apricot (Prunus mume). The enzyme has similar properties with HNL isolated from other Prunus species and is FAD containing enzyme. It accepts a large number of unnatural substrates (benzaldehyde and its variant) for the addition of HCN to produce the corresponding cyanohydrins in excellent optical and chemical yields. A new HPLC based enantioselective assay technique was developed for the enzyme, which promotes the addition of KCN to benzaldehyde in a buffered solution (pH=4.5).

Enzymatic Preparation of Optically Active Cyanohydrin Acetates

A series of cyanohydrin acetates (1)-(47) of widely varying structures, potential chiral building blocks for numerous synthetic applications, has been prepared in good chemical and often high optical yields by enzymatic hydrolysis of their racemic acetates in the presence of an ester hydrolase from Pseudomonas sp.