1425052-35-2

Upstream product

• 651-83-2 4-trifluoromethyl-2,3,5,6-tetrafluoroaniline 
• 79-03-8 propionyl chloride 
• 802294-64-0 propionic acid 

Downstream Products

• 1425052-45-4 N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)pent-4-ynamide 
• 1407870-22-7 N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butyramide 
• 1443771-38-7 3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide 
• 1638490-43-3 3-(4-chlorophenyl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide 
• 1638490-42-2 3-(3,4-dimethylphenyl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide 

Relevant academic research and scientific papers

Ligand-promoted alkylation of C(sp3)-H and C(sp2)-H bonds

9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp3) - H and C(sp2) - H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.

Palladium(0)-catalyzed alkynylation of C(sp3)-H bonds

The alkynylation of β-C(sp3)-H bonds in aliphatic amides with alkynyl halides has been enabled using Pd(0)/N-heterocyclic carbene (NHC) and Pd(0)/phosphine (PR3) catalysts. This is the first example of utilizing [AlkynylPd(II)Ln