N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propionamide

Base Information

• Chemical Name: N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propionamide
• CAS No.: 1425052-35-2
• Molecular Formula: C₁₀H₆F₇NO
• Molecular Weight: 289.153
• Mol file: 1425052-35-2.mol

Synonyms:N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propionamide

Chemical Property of N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propionamide

There total 2 articles about N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-trifluoromethyl-2,3,5,6-tetrafluoroaniline (651-83-2) + propionic acid (802294-64-0,79-09-4) → N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propionamide (1425052-35-2)

Guidance literature:

With oxalyl dichloride; In toluene; at 0 - 20 ℃; for 12.5h; Reflux; Inert atmosphere;

DOI:10.1021/ja400648w

Reference yield:

4-trifluoromethyl-2,3,5,6-tetrafluoroaniline (651-83-2) + propionyl chloride (79-03-8) → N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propionamide (1425052-35-2)

Guidance literature:

In toluene; Reflux;

DOI:10.1021/ja508165a

Reference yield: 80.0%

iodobenzene (591-50-4) + N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propionamide (1425052-35-2) → 4-phenyl-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)quinolin-2(1H)-one

Guidance literature:

With 2,5-dimethylpyridine; silver carbonate; palladium dichloride; In tert-Amyl alcohol; at 140 ℃; for 24h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior;

DOI:10.1002/anie.201403878

upstream raw materials:

4-trifluoromethyl-2,3,5,6-tetrafluoroaniline

propionic acid

propionyl chloride

Downstream raw materials:

N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)pent-4-ynamide

N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-3-p-tolylpropanamide

N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-3-(m-tolyl)propanamide