42773-97-7

Upstream product

• 77-78-1 dimethyl sulfate 
• 1040730-80-0 N-(2-bromophenyl)-2-methoxy-N-methyl-2-phenylacetamide 
• 1040730-81-1 N-(2-chlorophenyl)-2-methoxy-N-methyl-2-phenylacetic acid amide 
• 1040730-82-2 N-(2-iodophenyl)-2-methoxy-N-methyl-2-phenylacetamide 
• 7021-09-2 rac-methoxyphenylacetic acid 
• 1978-38-7 2-fluoro-N-methylaniline 
• 15757-32-1 3-hydroxy-1-methyl-3-phenyl-1,3-dihydro-2H-indol-2-one 
• 74-88-4 methyl iodide 
• 100-58-3 phenylmagnesium bromide 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 67-56-1 methanol 
• 1425058-79-2 1-methyl-2-oxo-3-phenylindolin-3-yl 2,2,2-trichloroacetimidate 
• 1333643-96-1 N-(2-fluorophenyl)-2-methoxy-N-methyl-2-phenylacetamide 
• 1146137-34-9 2-methoxy-N-methyl-N,2-diphenylacetamide 

Relevant academic research and scientific papers

Highly chemoselective synthesis of dimeric 2-oxindoles with a C-3/C-5′ linkage via Friedel-Crafts alkylations of 2-oxindoles with 3-hydroxy-2-oxindoles

Simple and convenient Lewis acid-catalyzed Friedel-Crafts alkylations of 2-oxindoles as electron rich aromatics with 3-hydroxy-2-oxindoles as electron deficient partners have been developed. The reaction afforded a variety of dimeric 2-oxindoles with a C-

Synthesis of 3,3-disubstituted oxindoles by one-pot integrated Br?nsted base-catalyzed trichloroacetimidation of 3-hydroxyoxindoles and Br?nsted acid-catalyzed nucleophilic substitution reaction

Treatment of 3-hydroxyoxindoles with trichloroacetonitrile (1.3 equiv.) and a catalytic amount of DBU (0.1 equiv.) followed by addition of nucleophiles (1.5 equiv.) and diphenylphosphoric acid (0.2 equiv.) afforded the 3,3-disubstituted oxindoles in good to excellent yields. DFT computations supported the notion that the reaction went through the 1-alkyl-2-oxo-2H-indol- 1-ium intermediate.

Transition-metal-free synthesis of oxindoles by potassium tert-butoxide-promoted intramolecular α-arylation

Potassium tert-butoxide-mediated intramolecular α-arylations of fluoro- and chloro-substituted anilides provide oxindoles in DMF at 80 °C. In this manner, diversely substituted products have been obtained in moderate to high yields.

Oxindole synthesis by direct coupling of Csp2-H and C sp3-H centers

(Chemical Equation Presented) An sp2/sp3 get-together: A novel and efficient method can be used to synthesize 3,3-disubstitued oxindoles by the direct intramolecular oxidative coupling of an aryl Csp2-H and a Csp3-H center (see scheme; DMF = N,N-dimethylformamide).

Air-stable secondary phosphine oxide as preligand for palladium-catalyzed intramolecular a-arylations with chloroarenes

A palladium catalyst derived from air-stable secondary phosphlne oxide (1-Ad)2P(O)H enabled efficient Intramolecular a-arylations of amides with aryl chlorides, which allowed for the synthesis of diversely substituted (aza)oxindoles.

Convenient synthesis of 3-alkoxy-3-aryloxindoles by intramolecular arylation of mandelic amides

(Chemical Equation Presented) Medicinally important 3-alkoxy-3- aryloxindoles are conveniently prepared by the rapid microwave-promoted palladium-catalyzed intramolecular enolate arylation of mandelate-derived anilides.