142516-74-3

Upstream product

• 100-39-0 benzyl bromide 
• 4654-08-4 5-(4'-hydroxyphenyl)pentanoic acid 
• 197796-01-3 5-(4-benzyloxyphenyl)pentanoic acid 

Downstream Products

• 154044-14-1 5-(4-benzyloxyphenyl)pentyl tosylate 
• 197796-04-6 25,27-bis(5-(4-benzyloxyphenyl)pentoxy)-26,28-dihydroxy-p-tert-butylcalix[4]arene 
• 197796-06-8 25,27-bis(5-(4-hydroxyphenyl)pentoxy)-26,28-dihydroxy-p-tert-butylcalix[4]arene 

Relevant academic research and scientific papers

Head-to-Tail Connected Double Calix[4]arenes

New macrotricyclic compounds consisting of two calix[4]arene substructures connected by aliphatic chains of various length (three to five carbon atoms) between two opposite p-positions and two distal phenolic oxygens have been synthesized. Starting with p-tert-butyl-calix[4]arene, two O-protected phenolic units are attached via ether links in 1,3-position by reaction with the corresponding tosylates. After deprotection, the new calix[4]arene is formed by fragment condensation with 2,6-tobromomethylated 4-alkylphenols. The structure of one example (8c) has been confirmed by single crystal X-ray analysis. Both calixarene parts assume the cone conformation, a molecule of acetonitrile being included in both cavities.