4654-08-4

Basic information

• Product Name: 5-(4-HYDROXYPHENYL)PENTANOIC ACID
• Synonyms: 5-(4-HYDROXYPHENYL)PENTANOIC ACID;5-(4-Hydroxyphenyl)
• CAS NO: 4654-08-4
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Mol File: 4654-08-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 116-120°C
• Boiling Point: 401°C at 760 mmHg
• Flash Point: 210.5°C
• Appearance: /
• Density: 1.178g/cm³
• Vapor Pressure: 3.77E-07mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Soluble in water.
• CAS DataBase Reference: 5-(4-HYDROXYPHENYL)PENTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-HYDROXYPHENYL)PENTANOIC ACID(4654-08-4)
• EPA Substance Registry System: 5-(4-HYDROXYPHENYL)PENTANOIC ACID(4654-08-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 4654-08-4(Hazardous Substances Data)

Usage

Uses

5-(4-Hydroxyphenyl)pentanoic acid is used as pharmaceutical intermediate.

InChI:InChI=1/C11H14O3/c12-10-7-5-9(6-8-10)3-1-2-4-11(13)14/h5-8,12H,1-4H2,(H,13,14)

Upstream product

• 4609-10-3 5-(4-methoxyphenyl)-5-oxopentanoic acid 
• 108-55-4 glutaric anhydride, 
• 100-66-3 methoxybenzene 
• 101268-18-2 methyl 5-(4-methoxyphenyl)pentanoate 
• 1316316-65-0 C₁₃H₁₆O₃ 
• 20401-88-1 3-(4-methoxyphenyl)propional 
• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 
• 15823-04-8 methyl 3-(4-methoxyphenyl)propionate 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 47172-89-4 diphenyl glutarate 
• 129649-59-8 (E)-5-(4-Benzyloxy-phenyl)-pent-2-enoic acid methyl ester 
• 68486-77-1 3-(4-(benzyloxy)phenyl)propanal 
• 50463-48-4 3-(4-benzyloxyphenyl)propanoic acid 
• 501-97-3 4-hydroxyphenylpropionic acid 

Downstream Products

• 197796-01-3 5-(4-benzyloxyphenyl)pentanoic acid 
• 1607800-32-7 C₄₇H₅₀ClNO₅Si 
• 1607800-33-8 C₄₇H₅₀ClNO₅Si 
• 1607800-34-9 C₄₇H₅₀ClNO₅Si 
• 1607800-35-0 RE₁₆₄ 
• 1607800-36-1 RE₁₆₃ 
• 1607800-37-2 RE₁₄₇ 
• 1607800-26-9 C₂₆H₂₈ClNO₂ 
• 1607800-27-0 C₂₆H₂₈ClNO₂ 
• 1607800-28-1 C₂₆H₂₈ClNO₂ 
• 1607800-47-4 C₂₆H₂₈ClNOS 
• 1607800-48-5 C₂₆H₂₈ClNOS 
• 1607800-49-6 C₂₆H₂₈ClNOS 
• 1607800-29-2 C₂₇H₃₀ClNOS 

Relevant articles and documents

Ion-transport activity of phenylpentanoic acids occurring in the roots of Athyrium yokoscense

5-(3′-Hydroxyphenyl)pentanoic add (1) and 5-(3′-methoxyphenyl)pentanoic acid (2) occurring in the roots of Athyrium yokoscense showed transport activity to alkaline and alkaline earth metal ions and heavy divalent metal ions.

RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells

New derivatives of Vaccinia H1-related phosphatase (VHR) inhibitor RE12 (5) were designed by replacing the long straight alkyl chain with other hydrophobic functionalities containing two aromatic rings, with the aim of obtaining potent, cell-active inhibitors. We established a direct coupling reaction between tetronic acid derivative and thioimidate to prepare the RE derivatives 6a-6i efficiently. These compounds all showed VHR-inhibitory activity in the presence of 0.001% NP-40, whereas RE12 (5) was inactive under this condition, even at 100 μM. Further structure-activity studies focused on terminal substitution afforded trifluoromethyl derivative 6k (RE176) and nitro derivative 6l (RE177). The IC50 value of 6l in the presence of NP-40 was almost equivalent to that of RE12 (5) in its absence. Compound 6k (RE176) potently inhibited proliferation of HeLa cells.

Initial structure-activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles

A nonpeptidyl GnRH receptor antagonist (1), with a unique 2-arylindole core, was identified through the Merck in-house screening for binding affinity on the rat GnRH receptor. SAR studies directed toward the alkoxy-ethanolamine and 2-aryl groups resulted in a simpler lead structure with improved activity. This compound 50 exhibits a 60-fold improvement in binding activity over our initial lead 1.