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14256-74-7

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14256-74-7 Usage

Uses

1-But-3-ynylpiperidine is used as a reagent in the synthesis of novel tetrahydronaphthyridines which have dual histamine H3 receptor antagonistic and serotonin reuptake transporter inhibitory activity.

Check Digit Verification of cas no

The CAS Registry Mumber 14256-74-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,2,5 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14256-74:
(7*1)+(6*4)+(5*2)+(4*5)+(3*6)+(2*7)+(1*4)=97
97 % 10 = 7
So 14256-74-7 is a valid CAS Registry Number.

14256-74-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-but-3-ynylpiperidine

1.2 Other means of identification

Product number -
Other names 1-but-3-ynyl-piperidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14256-74-7 SDS

14256-74-7Relevant articles and documents

DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY

-

Page/Page column 376; 377, (2019/11/12)

Provided herein are compounds of the Formula (I), (II), and (III), as well as pharmaceutically acceptable salts thereof, wherein the substituents are those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of oncologic diseases.

USE OF EMICORONS AS SELECTIVE INDUCERS OF DAMAGE TO THE TELOMERE DNA

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Page/Page column 32; 33, (2014/05/07)

The hydrosoluble emicoron derivatives of the general formula (I) are particularly effective as inducers of selective telomere and non- telomere DNA damage in tumour and transformed cells. The damage is measured as the ability to cause a number of TIF foci in transformed cells that is equal to or higher than 4 at a 0.1 uM dose of the compound of the formula (I). Such emicoron derivatives can be used in a kit together with other known anti-tumour drugs, such as, for example, topoisomerase I inhibitors, for the combined, simultaneous, delayed or sequential administration. The emicoron compounds of the formula (I) are particularly useful in the therapy of tumours that do not express p53 protein or express an inactive p53 protein and of tumours that maintain telomeres by mechanisms different from telomere maintenance by telomerase, and in the removal of cancer stem cells. Also, the method for the preparation of emicoron compounds of the formula (I), which envisages the use of intermediates such as the Ν,Ν'-bis [2-(1-piperidino)-ethyl] - 1-(1-piperidinyl)-7- [3-(1-piperidino)- butynyl]-perylene-3,4;9,10-tetracarboxyl diimide, is described.

A two-step, formal [4 + 2] approach toward piperidin-4-ones via au catalysis

Cui, Li,Peng, Yu,Zhang, Liming

supporting information; experimental part, p. 8394 - 8395 (2009/10/23)

(Chemical Equation Presented) An efficient, formal [4 + 2] synthesis of synthetically valuable piperidin-4-ones from secondary amines in two steps has been achieved via a key gold catalysis without the purification of tertiary amine intermediates. This reaction is selective toward the less-substituted alkyl group and shows moderate to excellent diastereoselectivities. Its synthetic potential in alkaloid synthesis is demonstratedin a highly diastereoselective synthesis of (±)-cermizine C.

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