1425925-85-4

Upstream product

• 1425925-81-0 (1R,2S)-1-amino-5-chloroindan-2-ol 
• 1425925-82-1 C₉H₁₀ClNO*C₈H₈O₃ 
• 1425925-83-2 2-[(1R,2S)-5-chloro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-1H-isoindole-1,3(2H)-dione 
• 1425925-84-3 2-[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]-1H-isoindole-1,3(2H)-dione 
• 3970-52-3 6-chloro-1H-indene 

Relevant academic research and scientific papers

INHIBITORS OF NEDD8-ACTIVATING ENZYME

Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyciopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.