3970-52-3

Upstream product

• 33781-38-3 5-chloro-2,3-dihydro-1H-inden-1-ol 
• 42348-86-7 5-chloro-1-indanone 
• 3946-29-0 3,4'-Dichloropropiophenone 
• 108-90-7 chlorobenzene 
• 104-15-4 toluene-4-sulfonic acid 
• 1313762-44-5 2-vinyl-5-chlorobenzaldehyde 
• 174265-12-4 2-bromo-5-chlorobenzaldehyde 

Downstream Products

• 74444-81-8 5-chloro-1,3-dihydro-2H-inden-2-one 
• 74444-76-1 acide amino-2 chloro-5 indane carboxylique-2 
• 62882-02-4 6-chloroisoquinoline 
• 1425925-85-4 (1R,2S)-5-chloro-2-methoxyindan-1-amine 
• 1425925-82-1 C₉H₁₀ClNO*C₈H₈O₃ 

Relevant academic research and scientific papers

Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions

Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described.

Selective, Scalable Synthesis of C60-Fullerene/Indene Monoadducts Using a Microwave Flow Applicator

The synergy of continuous processing and microwave heating technologies has unlocked scalable (g/h), safe and efficient reaction conditions for synthesis of fullerene/indene-based organic photovoltaic acceptor materials in a nonchlorinated solvent with levels of productivity unparalleled by previous syntheses. The microwave flow reactor sustains high temperature while employing short residence times, reaction conditions which uniquely allow the selective synthesis of fullerene/indene monoadducts. Design of experiments analysis revealed residence time as the most crucial factor for conversion and selectivity control.

Rhodium(II)- or Copper(I)-Catalyzed Formal Intramolecular Carbene Insertion into Vinylic C(sp2)?H Bonds: Access to Substituted 1H-Indenes

A rhodium(II)- or copper(I)-catalyzed formal intramolecular carbene insertion into vinylic C(sp2)?H bonds is reported herein. This method provides straightforward access to 1H-indenes with high efficiency and excellent functional-group compatibility. Mechanistically, the reaction is proposed to involve the following sequence: metal carbene formation, intramolecular nucleophilic addition of the double bond to the electron-deficient carbene carbon atom, dearomatization, and finally a 1,5-H shift.

Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors

Botulinum neurotoxins are the most toxic proteins currently known. Based on a recently identified potent lead structure, 2,4-dichlorocinnamic acid hydroxamate, herein we report on the structure-activity relationship of a series of hydroxamate BoNT/A inhibitors. Among them, 2-bromo-4-chlorocinnamic acid hydroxamate, 2-methyl-4-chlorocinnamic acid hydroxamate, and 2-trifluoromethyl-4-chlorocinnamic acid hydroxamate displayed comparable inhibitory activity to that of the lead structure.

Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators

The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are tricyclic indeno-pyrrole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).