1425927-02-1Relevant articles and documents
Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins
Wu, Jiang,Shin, Julia,Williams, Cara M. M.,Geoghegan, Kieran F.,Wright, Stephen W.,Limburg, David C.,Sahasrabudhe, Parag,Bonin, Paul D.,Lefker, Bruce A.,Ramsey, Simeon J.
, p. 1871 - 1878 (2014)
Bromodomain-containing proteins form the signal-reading element of a principal system for the control of gene expression in eukaryotes. Their potential as targets for selective drug action is increasingly being assessed and exploited. Deep characterizatio
NOVEL HETEROCYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS
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Page/Page column 49, (2013/03/26)
Disclosed are compounds of Formula (I): (I) which are useful as bromodomain inhibitors. Pharmaceutical compositions containing compounds of Formula (I) and the use of compounds of Formula (I) to treat diseases or disorders that are bromodomain-dependent are also disclosed. Methods for preparing and using these compounds are further described.