142606-22-2

Upstream product

• 75-44-5 phosgene 
• 54837-17-1 N-Benzyloxy-D-Alanin 
• 622-33-3 N-benzyloxyamine 
• 142696-72-8 (R)-2-Benzyloxyamino-propionic acid tert-butyl ester 

Downstream Products

• 142606-24-4 (R)-(-)-N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-benzyloxy-urea 
• 142606-23-3 (R)-(+)-N-[1-(benzo[b]thiophen-2-yl)ethyl]-O-benzylhydroxylamine 
• 142696-73-9 (R)-3-Benzyloxy-4-methyl-oxazolidine-2,5-dione 

Relevant academic research and scientific papers

Synthesis of Chiral Zileuton, A Potent And Selective Inhibitor Of 5-Lipoxygenase

Coupling and intramolecular Wittig reaction of N-benzyloxy-D-alanine anhydride (13) and (2-Mercaptophenyl)methyltriphenylphosphonium bromide (3) were used as key steps to prepare (+)-enantiomer of zileuton (1), a potent and selective inhibitor of 5-lipoxygenase.