1426083-95-5

Basic information

• Product Name: tert-butyl N-{5-[4-(6-fluorohexyl)phenethyl]-2,2-dimethyl-1,3-dioxan-5-yl}-carbamate
• Synonyms: tert-butyl N-{5-[4-(6-fluorohexyl)phenethyl]-2,2-dimethyl-1,3-dioxan-5-yl}-carbamate
• CAS NO: 1426083-95-5
• Molecular Weight: 437.595
• Mol File: 1426083-95-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl N-{5-[4-(6-fluorohexyl)phenethyl]-2,2-dimethyl-1,3-dioxan-5-yl}-carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-{5-[4-(6-fluorohexyl)phenethyl]-2,2-dimethyl-1,3-dioxan-5-yl}-carbamate(1426083-95-5)
• EPA Substance Registry System: tert-butyl N-{5-[4-(6-fluorohexyl)phenethyl]-2,2-dimethyl-1,3-dioxan-5-yl}-carbamate(1426083-95-5)

Safety Data

• Hazardous Substances Data: 1426083-95-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1426083-92-2 tert-butyl [5-(4-iodostyryl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate 
• 1426083-93-3 tert-butyl {5-[4-(6-hydroxyhex-1-yn-1-yl)styryl]-2,2-dimethyl-1,3-dioxan-5-yl}-carbamate 
• 1426083-94-4 tert-butyl N-{5-[4-(6-hydroxyhexyl)phenethyl]-2,2-dimethyl-1,3-dioxan-5-yl}-carbamate 
• 364631-72-1 tert-butyl N-[5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate 
• 146651-71-0 N-(tert-butyloxycarbonyl)-2-amino-2-(hydroxymethyl)propane-1,3-diol 
• 364631-73-2 tert-butyl 5-formyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate 

Downstream Products

• 1426083-96-6 2-amino-2-(4-(6-fluorohexyl)phenethyl)propane-1,3-diol 

Relevant articles and documents

Synthesis and evaluation of fluorinated fingolimod (FTY720) analogues for sphingosine-1-phosphate receptor molecular imaging by positron emission tomography

Sphingosine-1-phosphate (S1P) is a lysophospholipid that evokes a variety of biological responses via stimulation of a set of cognate G-protein coupled receptors (GPCRs): S1P1-S1P5. S1P and its receptors (S1PRs) play important roles in the immune, cardiovascular, and central nervous systems and have also been implicated in carcinogenesis. Recently, the S1P analogue Fingolimod (FTY720) has been approved for the treatment of patients with relapsing multiple sclerosis. This work presents the synthesis of various fluorinated structural analogues of FTY720, their in vitro and in vivo biological testing, and their development and application as [18F]radiotracers for the study of S1PR biodistribution and imaging in mice using small-animal positron emission tomography (PET).

NEW LIGANDS FOR TARGETING OF S1P RECEPTORS FOR IN VIVO IMAGING AND TREATMENT OF DISEASES

The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P receptors, in particular, in diseases which are connected to the regulatory function of sphingosine-1-phosphate (S1P) and its analogues, such as inflammation, pain, autoimmune diseases and cardiovascular diseases.