1426125-45-2

Basic information

• Product Name: tert-butyl N-benzyl-N-[(3R,4R)-3-hydroxypiperidin-4-yl]carbamate
• Synonyms: tert-butyl N-benzyl-N-[(3R,4R)-3-hydroxypiperidin-4-yl]carbamate
• CAS NO: 1426125-45-2
• Molecular Weight: 306.405
• Mol File: 1426125-45-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl N-benzyl-N-[(3R,4R)-3-hydroxypiperidin-4-yl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-benzyl-N-[(3R,4R)-3-hydroxypiperidin-4-yl]carbamate(1426125-45-2)
• EPA Substance Registry System: tert-butyl N-benzyl-N-[(3R,4R)-3-hydroxypiperidin-4-yl]carbamate(1426125-45-2)

Safety Data

• Hazardous Substances Data: 1426125-45-2(Hazardous Substances Data)

Upstream product

• 1334700-32-1 (-)-(3R,4R)-1-benzyl-4-(benzylamino)piperidin-3-ol 
• 1426125-50-9 C₁₉H₂₄N₂O 
• 1426125-49-6 C₁₉H₂₀N₂O₂*C₂H₂O₄ 
• 118867-99-5 (2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>oct-6-en-8-one 
• 118918-76-6 (2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-8-one 
• 66673-40-3 (R)-5-hydroxymethylpyrrolidin-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1384733-04-3 C₁₀H₁₀O₄*C₁₉H₂₄N₂O 
• 725715-12-8 3-(phenylmethyl)-7-oxa-3-azabicyclo[4.1.0]heptane 
• 40240-12-8 1-benzyl-1,2,3,6-tetrahydropyridine 
• 110-86-1 pyridine 

Downstream Products

• 1426125-46-3 C₃₁H₃₈N₆O₄ 
• 1426125-47-4 C₂₆H₃₀N₆O₂ 

Relevant articles and documents

Selection and scale-Up evaluation of an alternative route to (-)-(3R,4R)-1-Benzyl-4-(benzylamino)piperidin-3-ol

An efficient, scalable synthesis of (-)-(3R,4R)-1-benzyl-4-(benzylamino) piperidin-3-ol (4) is described. Reduction of the pyridinium salt prepared from pyridine and benzyl chloride generated the corresponding tetrahydropyridine derivative. A two-stage epoxidation, followed by ring-opening of the epoxide with BnNH2, established the regiochemistry of the amino alcohol and served to set the trans-relationship between the amine and the hydroxyl group. The resulting racemic intermediate was then resolved by salt formation with (R)-O-acetyl mandelic acid. The process produced the O-acetyl mandelic acid salt of (-)-4 in 27% overall yield from benzyl chloride.