1426125-57-6

Basic information

• Product Name: C₁₉H₂₄N₆O₂*C₂H₂O₄
• Synonyms: C₁₉H₂₄N₆O₂*C₂H₂O₄
• CAS NO: 1426125-57-6
• Molecular Weight: 458.474
• Mol File: 1426125-57-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₄N₆O₂*C₂H₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₄N₆O₂*C₂H₂O₄(1426125-57-6)
• EPA Substance Registry System: C₁₉H₂₄N₆O₂*C₂H₂O₄(1426125-57-6)

Safety Data

• Hazardous Substances Data: 1426125-57-6(Hazardous Substances Data)

Upstream product

• 1007596-94-2 (3R,4R)-4-aminopiperidin-3-ol 
• 118918-76-6 (2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-8-one 
• 118867-99-5 (2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>oct-6-en-8-one 
• 1426125-49-6 C₁₉H₂₀N₂O₂*C₂H₂O₄ 
• 1426125-50-9 C₁₉H₂₄N₂O 
• 1334700-32-1 (-)-(3R,4R)-1-benzyl-4-(benzylamino)piperidin-3-ol 
• 1408065-00-8 (4-(3-methoxyphenylamino)pyrrolo[1,2-f][1,2,4]-triazin-5-yl)methanol 
• 66673-40-3 (R)-5-hydroxymethylpyrrolidin-2-one 
• 144-62-7 oxalic acid 

Relevant articles and documents

Evolution of the process for the preparation of a selective erbb vegf receptor inhibitor

An efficient synthetic route to the potent and selective ErbB VEGF receptor inhibitor, BMS-690514 (1) is described. Strategic modifications in both approach and procedure addressed several issues, which led to a safe, efficient, and economical process for the preparation of multi-kilogram quantities of 1. The convergent route involves alkylation of a suitably protected (3R,4R)-4-aminopiperidin-3-ol with the triethyl(alkyl)ammonium salt of a functionalized pyrrolotriazine 3a followed by deprotection to provide 1 as the crystalline free base. Georg Thieme Verlag Stuttgart - New York.