1426307-36-9Relevant academic research and scientific papers
Facile synthesis of versatile enantioenriched α-substituted hydroxy esters through a Bronsted acid catalyzed kinetic resolution
Qabaja, Ghassan,Wilent, Jennifer E.,Benavides, Amanda R.,Bullard, George E.,Petersen, Kimberly S.
supporting information, p. 1266 - 1269 (2013/05/09)
An efficient synthesis of enantioenriched α-substituted γ-hydroxy esters via a kinetic resolution event is described. Bulky racemic esters in the presence of a chiral Bronsted acid selectively lactonize to yield a recoverable enantioenriched hydroxy ester and lactone. These esters are highly versatile building blocks that can readily be converted to synthetically useful materials.
