1426318-90-2Relevant academic research and scientific papers
Optically active α-amino group of the β-hydroxy amino acid derivative and its preparation method and application
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Paragraph 0107-0109, (2016/10/24)
The invention relates to an alpha-amino beta-hydroxy amino acid derivative shown as formula (I) with optical activity and a preparation method and application thereof, the alpha-amino beta-hydroxy amino acid derivative with optical activity is obtained by the reaction of three components at-10 DEG C by sue of a diazo compound, N-aryl substituted glycine ester, 2, 3-dichloro-5, 6-dicyano-1, 4 - benzoquinone and water as raw materials, rhodium acetate and chiral phosphoric acid as catalysts and an organic solvent as a solvent. The raw materials are cheap and easily obtained, two chiral carbons can be simultaneously constructed, the preparation route is short, the operation is simple and safe, the reaction condition is mild, the atom economy is high, the selectivity is high, and the alpha-amino beta-hydroxy amino acid derivative can be conveniently obtained, and diverse compound skeletons can be provided for use in screening of new drugs and pharmaceutical fields.
A highly enantioselective four-component reaction for the efficient construction of chiral β-hydroxy-α-amino acid derivatives
Qian, Yu,Jing, Changcheng,Liu, Shunying,Hu, Wenhao
supporting information, p. 2700 - 2702 (2013/05/08)
An enantioselective four-component reaction of a diazoketone, water, an aniline and ethyl glyoxylate in the presence of catalytic Rh2(OAc) 4 and a chiral Br?nsted acid was developed to efficiently produce β-hydroxy-α-amino acid derivatives in good yields with high diastereoselectivity and enantioselectivity. The Royal Society of Chemistry 2013.
