1426814-68-7Relevant articles and documents
Improved synthesis of rupintrivir
Lin, Daizong,Qian, Wangke,Hilgenfeld, Rolf,Jiang, Hualiang,Chen, Kaixian,Liu, Hong
, p. 1101 - 1107 (2012)
An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.