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223526-67-8

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223526-67-8 Usage

Uses

(αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid can be used in the preparation of rhinovirus protease inhibitors and peptidomimetic α,β-unsaturated esters.

Check Digit Verification of cas no

The CAS Registry Mumber 223526-67-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,5,2 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 223526-67:
(8*2)+(7*2)+(6*3)+(5*5)+(4*2)+(3*6)+(2*6)+(1*7)=118
118 % 10 = 8
So 223526-67-8 is a valid CAS Registry Number.

223526-67-8Relevant articles and documents

Improved synthesis of rupintrivir

Lin, Daizong,Qian, Wangke,Hilgenfeld, Rolf,Jiang, Hualiang,Chen, Kaixian,Liu, Hong

, p. 1101 - 1107 (2012/09/08)

An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.

An efficient and tunable route to AG7088, a rhinovirus protease inhibitor

Ma, Dawei,Xie, Weiqing,Zou, Bin,Lei, Qiong,Pei, Duanqing

, p. 8103 - 8105 (2007/10/03)

Aldol reaction of N,N-dibenzyl valinal with propiolic acid ethyl ester derived lithium reagent provides anti-aminoalcohol 8 and syn-aminoalcohol 9, which are converted into the lactone 6 via two different routes. Alkylation of 6 followed by lactone ring o

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