223526-67-8Relevant articles and documents
Improved synthesis of rupintrivir
Lin, Daizong,Qian, Wangke,Hilgenfeld, Rolf,Jiang, Hualiang,Chen, Kaixian,Liu, Hong
, p. 1101 - 1107 (2012/09/08)
An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.
An efficient and tunable route to AG7088, a rhinovirus protease inhibitor
Ma, Dawei,Xie, Weiqing,Zou, Bin,Lei, Qiong,Pei, Duanqing
, p. 8103 - 8105 (2007/10/03)
Aldol reaction of N,N-dibenzyl valinal with propiolic acid ethyl ester derived lithium reagent provides anti-aminoalcohol 8 and syn-aminoalcohol 9, which are converted into the lactone 6 via two different routes. Alkylation of 6 followed by lactone ring o