142697-17-4Relevant articles and documents
Enantioselective synthesis of 5,7-bicyclic ring systems from axially chiral allenes using a Rh(I)-catalyzed cyclocarbonylation reaction
Grillet, Francois,Brummond, Kay M.
, p. 3737 - 3754 (2013/06/04)
A transfer of chirality in an intramolecular Rh(I)-catalyzed allenic Pauson-Khand reaction (APKR) to access tetrahydroazulenones, tetrahydrocyclopenta[c]azepinones and dihydrocyclopenta[c]oxepinones enantioselectively (22-99% ee) is described. The substit
Preparation and use of enantioenriched Allenylsilanes for the stereoselective synthesis of homopropargylic ethers
Brawn, Ryan A.,Panek, James S.
, p. 2689 - 2692 (2008/02/08)
Equation Presented A convenient procedure for the synthesis of highly enantioenriched allenylsilanes by Johnson orthoester Claisen rearrangement of 1-silyl propargylic alcohols is described. Allenylsilanes are then used as carbon nucleophiles in three-com
Enantioselective synthesis of both enantiomers of various propargylic alcohols by use of two oxidoreductases
Schubert, Thomas,Hummel, Werner,Kula, Maria-Regina,Mueller, Michael
, p. 4181 - 4187 (2007/10/03)
The oxidoreductases Lactobacillus brevis alcohol dehydrogenase (LBADH) and Candida parapsilosis carbonyl reductase (CPCR) are suitable catalysts for the reduction of ketones to afford enantiopure sec. alcohols. A broad variety of alkynones (1, 3, and 5) are accepted as substrates and the corresponding propargylic alcohols (2, 4, and 6) are obtained in good yield and excellent enantiomeric excess. By changing the steric demand of the substituents the ee values can be adjusted and even the configurations of the products can be altered.