1427161-79-2Relevant academic research and scientific papers
Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives
Maillard, Ludovic T.,Bertout, Sébastien,Quinonéro, Ophélie,Akalin, Gül?en,Turan-Zitouni, Gülhan,Fulcrand, Pierre,Demirci, Fatih,Martinez, Jean,Masurier, Nicolas
, p. 1803 - 1807 (2013/04/10)
Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.
