14273-06-4

Basic information

• Product Name: 1-Propynylethyl ether
• Synonyms: 1-Ethoxy-1-propyne;1-Propynylethyl ether
• CAS NO: 14273-06-4
• Molecular Formula: C₅H₈O
• Molecular Weight: 0
• Mol File: 14273-06-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 84°C (estimate)
• Appearance: /
• Density: 0.8276
• Refractive Index: 1.4039
• CAS DataBase Reference: 1-Propynylethyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propynylethyl ether(14273-06-4)
• EPA Substance Registry System: 1-Propynylethyl ether(14273-06-4)

Safety Data

• Hazardous Substances Data: 14273-06-4(Hazardous Substances Data)

Usage

Physical state

Colorless, flammable liquid.

Usage

Commonly used as a solvent in organic synthesis, a starting material in the production of pharmaceuticals and other organic compounds, a propellant in aerosol products, and a component in polymer coatings.

Odor

Strong, sweet odor.

Hazard

Volatile and potentially hazardous substance that should be handled with care.

Versatility

A versatile and useful compound in the field of chemistry and industry.

Upstream product

• 21204-64-8 β-bromopropenyl ethyl ether 
• 927-80-0 1-ethoxyacetylene 
• 74-88-4 methyl iodide 
• 928-56-3 E/Z-2-chlorovinyl ethyl ether 
• 928-55-2 ethyl 1-propenyl ether 
• 34600-11-8 (E)-2-bromo-1-ethoxy-propene 
• 34600-12-9 (Z)-1-ethoxy-2-bromopropene 
• 74-83-9 methyl bromide 
• 621-62-5 chloroacetaldehyde diethyl acetal 

Downstream Products

• 620-71-3 N-(phenyl)-2-methylacetamide 
• 89534-52-1 3-hydroxy-2-methyl-propionic acid ethyl ester 
• 6613-56-5 3-ethoxy-2,4-dimethyl-cyclobutenone 
• 58625-96-0 ethyl 2-methyl-2-pentenoate 
• 20841-34-3 1-Aethoxy-1-phenyl-2-methylen-benzocyclobuten 
• 30788-22-8 3.7-Diketo-2.6.6-trimethyl-7-phenylheptansaeure-ethylester 
• 93351-14-5 1-Aethoxy-1-phenylmercapto-propen 
• 30788-21-7 3.7-Diketo-2-methyl-7-phenyl-heptansaeure-ethylester 
• 57642-62-3 2-methyl-3-phenylbenzothiophen 
• 84538-78-3 3-Ethoxy-4-methyl-1-phenylisoquinoline 
• 84538-74-9 7-Ethoxy-1-methyl-5-phenyl-3,4-benzo-2,6-thiazabicyclo<3.2.0>hepta-3,6-diene 
• 83463-85-8 4-ethoxy-3-methyl-2-phenylquinoline 
• 105-37-3 Ethyl propionate 
• 142746-93-8 pentacarbonyl{3-ethoxy-2-methyl-4,4-diphenyl-2-cyclobuten-1-ylidene}tungsten 

Relevant articles and documents

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5,6,7-Trimethylocta-2,5-dien-4-one - A suspected odorant with surprising olfactory properties

5,6,7-Trimethylocta-2,5-dien-4-one (3) was suspected of being a trace component smelling of damascone in a crude complex reaction product. Although this trace component eventually turned out to be the constitutional isomer 2-methyl-3-isopropylhepta-2,5-dien-4-one (4), the title compound 3 was found to possess even superior fruity, rosy odor characteristics, reminiscent of apples, plums, raisins and other dried fruits, and these odor characteristics are, surprisingly, due mainly to its (5Z)-isomer. The synthesis of 3 commenced with the preparation of 1-ethoxyprop-1-yne (11) from 2-chloro-1,1-diethoxyethane (9). Borontrifluoride-catalyzed addition of methyl isopropyl ketone (10) to 11 provided ethyl 2,3,4-trimethylpent-2-enoate (8), which was transformed into the target molecule 3 by Grignard reaction with propen-1-ylmagnesium bromide and in situ enolization. Further derivatives 13-16 provide more insight into the structure-odor correlation of damascone-type odorants, and the use of 3 in perfumery is illustrated by a composition formula of a demonstration perfume.