14273-76-8

Upstream product

• 14273-42-8 (2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid ethyl ester 
• 123-25-1 succinic acid diethyl ester 
• 14273-42-8 ethyl 2-(4-hydroxy-2-methylpyrimidin-5-yl)acetate 
• 5472-38-8 diethyl 2-formylbutanedioate 

Downstream Products

• 95-02-3 5-(aminomethyl)-2-methylpyrimidin-4-amine 
• 31375-20-9 4-Amino-2-methyl-5-thioformamidomethylpyrimidin 
• 1886-34-6 2-methyl-4-amino-5-formylaminomethylpyrimidine 
• 118801-71-1 5,7-dihydro-2-methyl-6H-pyrrolo[2,3-d]pyrimidin-6-one 

Relevant academic research and scientific papers

Convenient synthesis of 2-substituted 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones

A new synthetic route was elaborated at our laboratory providing a convenient access to 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones (diazaoxindoles), a compound family of biological relevance. Treatment of the easily available ethyl 2-(4-chloropyrimidin-5-yl)acetate derivatives with ammonia afforded the corresponding 2-(4-aminopyrimidin-5-yl)acetamides, which were finally cyclized to the target compounds.

Oxindolylquinazoline derivatives as angiogenesis inhibitors

The invention relates to compounds of formula (I) and salts thereof as further defined herein, wherein ring Z is a 6-membered heterocyclic ring containing 1 to 3 nitrogen atoms, and the use of such compounds and salts to inhibit the effects of VEGF and FGF, and in the treatment of a number of disease states including cancer and rheumatoid arthritis.