1427319-43-4

Basic information

• Product Name: (±)-1-benzyl-5-(iodomethyl)piperidin-2-one
• Synonyms: (±)-1-benzyl-5-(iodomethyl)piperidin-2-one
• CAS NO: 1427319-43-4
• Molecular Weight: 329.181
• Mol File: 1427319-43-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (±)-1-benzyl-5-(iodomethyl)piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-1-benzyl-5-(iodomethyl)piperidin-2-one(1427319-43-4)
• EPA Substance Registry System: (±)-1-benzyl-5-(iodomethyl)piperidin-2-one(1427319-43-4)

Safety Data

• Hazardous Substances Data: 1427319-43-4(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 744212-68-8 (±)-1-benzyl-5-(hydroxymethyl)piperidin-2-one 

Downstream Products

• 1427319-48-9 3-(((tert-butoxycarbonyl)amino)methyl)cyclobutanecarboxylic acid 
• 1352925-73-5 3-benzyl-3-aza-bicyclo[3.1.1]heptan-2-one 
• 1352925-67-7 3-benzyl-3-azabicyclo[3.1.1]heptane 

Relevant articles and documents

ARYL, HETEROARY, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Synthesis of a conformationally constrained δ-amino acid building block

Conformationally restricted amino acids are important components in peptidomimetics and drug design. Herein, we describe the synthesis of a novel, non-proteinogenic constrained delta amino acid containing a cyclobutane ring, cis-3(aminomethyl)cyclobutane