1427329-99-4

Upstream product

• 162789-30-2 methyl (3R)-6-(tert-butyldiphenylsiloxy)-3-methylhexanoate 
• 20425-49-4 methyl (R)-3-methyl-6-hydroxyhexanoate 
• 18951-85-4 (R)-citronellic acid 
• 20425-48-3 methyl (R)-(+)-citronellate 
• 342374-96-3 (R)-6-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-hexanal 
• 173864-72-7 (3R)-6-(tert-butyldiphenylsiloxy)-3-methyl-1-hexanol 
• 166239-59-4 (2R)-2-Methyl-5-<<(1,1-dimethylethyl)diphenylsilyl>oxy>pentanal 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 123595-52-8 (2R)-2-Methyl-5-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-1-pentanol 
• 1427329-98-3 C₃₂H₄₃NO₃Si 
• 114671-83-9 1-(t-butyldiphenylsilyloxy)-3-iodopropane 

Downstream Products

• 1427329-81-4 C₁₇H₂₁NO₂S 
• 1427330-02-6 (R)-1,4-dimethyl-2-(p-tosyl)-4,5,6,7-tetrahydro-2H-isoindole 

Relevant academic research and scientific papers

Total Syntheses of Strasseriolide A and B, Antimalarial Macrolide Natural Products

We report the first total syntheses of strasseriolide A and B. Strasseriolide B shows potent activity against the wild-type malaria parasite Plasmodium falciparum and good activity against a chloroquine-resistant strain. A convergent strategy was envisioned with an aldehyde-acid fragment and a vinyl iodide-alcohol fragment. Both fragments were prepared using chiral pool starting materials. They were combined with a Yamaguchi esterification and cyclized with a Nozaki-Hiyama-Kishi reaction. Strasseriolide B was assembled in a 16-step LLS.

Application of in situ-generated Rh-bound trimethylenemethane variants to the synthesis of 3,4-fused pyrroles

Rh-bound trimethylenemethane variants generated from the interaction of a Rh-carbenoid with an allene have been applied to the synthesis of substituted 3,4-fused pyrroles. The pyrrole products are useful starting points for the syntheses of various dipyrromethene ligands. Furthermore, the methodology has been applied to a synthesis of the natural product cycloprodigiosin, which demonstrates antitumor and immunosuppressor activity.