1427348-99-9Relevant academic research and scientific papers
Asymmetric transfer hydrogenation of imines catalyzed by a Noyori-type Ru(II) complex - A parametric study
Pechacek, Jan,Vaclavik, Jiri,Prech, Jan,Sot, Petr,Januscak, Jakub,Vilhanova, Beata,Vavrik, Jiri,Kuzma, Marek,Kacer, Petr
, p. 233 - 239 (2013)
We present, to the best of our knowledge, the first parametric study of the asymmetric transfer hydrogenation of imines catalyzed by a Noyori-type catalytic complex based on ruthenium. A model imine for this study was 1-methyl-3,4-dihydroisoquinoline, and a well-known complex RuCl(η 6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine) was chosen as the model catalyst. The reactions were performed in the presence of a formic acid-triethylamine mixture as the source of hydrogen. The parameters examined include general parameters, for example, concentration, temperature, and substrate-to-catalyst molar ratio, as well as parameters specific to this particular reaction, such as the amount of the hydrogenation mixture used, the ratio of its components, or the inhibitive effect of carbon dioxide. During this study, several unexpected parameters worth further investigation have emerged.
Molecular structure effects in the asymmetric transfer hydrogenation of functionalized dihydroisoquinolines on (S,S)-[RuCl(η 6-p-cymene) TsDPEN]
Vaclavik, Jiri,Pechacek, Jan,Vilhanova, Beata,Sot, Petr,Januscak, Jakub,Matousek, Vaclav,Prech, Jan,Bartova, Simona,Kuzma, Marek,Kacer, Petr
, p. 555 - 562 (2013/07/19)
The asymmetric transfer hydrogenation of five dihydroisoquinolines (DHIQs) was studied by NMR spectroscopy. The DHIQs differed by substitution with methoxy groups, which had a significant effect upon the reaction performance in terms of reaction rate and enantioselectivity. The differences are most probably related to the basicity of DHIQs.
