1427669-83-7Relevant articles and documents
Directed Decarbonylation of Unstrained Aryl Ketones via Nickel-Catalyzed C - C Bond Cleavage
Zhao, Tian-Tian,Xu, Wen-Hua,Zheng, Zhao-Jing,Xu, Peng-Fei,Wei, Hao
, p. 586 - 589 (2018/01/26)
The nickel-catalyzed decarbonylation of unstrained diaryl ketones has been developed. The reaction is catalyzed by a combination of Ni(cod)2 and an electron-rich N-heterocyclic carbene ligand. High functional group tolerance and excellent yields (up to 98%) are observed. This strategy provides an alternative and versatile approach to construct biaryls using an inexpensive nickel catalyst.
Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C-H activation
Zhao, Yaping,Sharma, Upendra K.,Schr?der, Felix,Sharma, Nandini,Song, Gonghua,Van Der Eycken, Erik V.
, p. 32559 - 32563 (2017/07/07)
A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as addit
Merger of Visible-Light Photoredox Catalysis and C-H Activation for the Room-Temperature C-2 Acylation of Indoles in Batch and Flow
Sharma, Upendra K.,Gemoets, Hannes P. L.,Schr?der, Felix,No?l, Timothy,Van Der Eycken, Erik V.
, p. 3818 - 3823 (2017/06/19)
A mild and versatile protocol for the C-H acylation of indoles via dual photoredox/transition-metal catalysis was established in batch and flow. The C-H bond functionalization occurred selectively at the C-2 position of N-pyrimidylindoles. This room-temperature protocol tolerated a wide range of functional groups and allowed for the synthesis of a diverse set of acylated indoles. Various aromatic as well as aliphatic aldehydes (both primary and secondary) reacted successfully. Interestingly, significant acceleration (20 to 2 h) and higher yields were obtained under micro flow conditions.
Dual visible-light photoredox and palladium(II) catalysis for dehydrogenative C2-acylation of indoles at room temperature
Manna, Manash Kumar,Bairy, Gurupada,Jana, Ranjan
supporting information, p. 5899 - 5903 (2017/07/25)
A highly regioselective direct C2-acylation of N-pyrimidine protected indoles with aldehydes is reported at room temperature through the merger of visible light photoredox and palladium(ii) catalysis. Late-stage acylation of tryptophan, selective mono-acylation of carbazole and the syntheses of tubulin inhibitors D-64131 and D-68144 are also demonstrated.
Palladium-catalyzed C2-acylation of indoles with α-diketones assisted by the removable N-(2-pyrimidyl) group
Li, Chunpu,Zhu, Wei,Shu, Shuangjie,Wu, Xiaoming,Liu, Hong
, p. 3743 - 3750 (2015/06/16)
An effective and practical palladium-catalyzed C2-acylation method was successfully developed for the synthesis of 2-acylindoles. A variety of 2-acylindoles were readily prepared from N-pyrimidyl indoles in moderate to good yields. This methodology offers
Synthesis of 2-Acylated Indoles through Palladium-Catalyzed Dehydrogenative Coupling of N -Pyrimidine-Protected Indoles with Aldehydes and Ethyl Glyoxylate
Wang, Wenduo,Liu, Jidan,Gui, Qingwen,Tan, Ze
supporting information, p. 771 - 778 (2015/03/30)
C2-Acylated indoles have been synthesized in good yields through palladium-catalyzed dehydrogenative coupling of N-pyrimidine-protected indoles using aldehydes as the source of acyl reagent and tert-butyl hydroperoxide as the oxidant. 2-Indole carboxylate
Palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids
Pan, Changduo,Jin, Hongming,Liu, Xu,Cheng, Yixiang,Zhu, Chengjian
supporting information, p. 2933 - 2935 (2013/04/24)
A palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids was achieved. This protocol represents a novel and complementary approach to 2-aroylindoles. The Royal Society of Chemistry 2013.
