1427669-83-7

Upstream product

• 221044-05-9 N-(2-pyrimidyl)indole 
• 7099-91-4 p-methoxybenzoylformic acid 
• 105-13-5 4-Methoxybenzyl alcohol 
• 104-93-8 p-methylanizole 
• 120-72-9 indole 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 104749-68-0 (1H-indol-2-yl)(4-methoxyphenyl)methanone 
• 1310708-92-9 2-(4-methoxyphenyl)-1-(pyrimidin-2-yl)-1H-indole 

Relevant academic research and scientific papers

Directed Decarbonylation of Unstrained Aryl Ketones via Nickel-Catalyzed C - C Bond Cleavage

The nickel-catalyzed decarbonylation of unstrained diaryl ketones has been developed. The reaction is catalyzed by a combination of Ni(cod)2 and an electron-rich N-heterocyclic carbene ligand. High functional group tolerance and excellent yields (up to 98%) are observed. This strategy provides an alternative and versatile approach to construct biaryls using an inexpensive nickel catalyst.

Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C-H activation

A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as addit

Merger of Visible-Light Photoredox Catalysis and C-H Activation for the Room-Temperature C-2 Acylation of Indoles in Batch and Flow

A mild and versatile protocol for the C-H acylation of indoles via dual photoredox/transition-metal catalysis was established in batch and flow. The C-H bond functionalization occurred selectively at the C-2 position of N-pyrimidylindoles. This room-temperature protocol tolerated a wide range of functional groups and allowed for the synthesis of a diverse set of acylated indoles. Various aromatic as well as aliphatic aldehydes (both primary and secondary) reacted successfully. Interestingly, significant acceleration (20 to 2 h) and higher yields were obtained under micro flow conditions.

Dual visible-light photoredox and palladium(II) catalysis for dehydrogenative C2-acylation of indoles at room temperature

A highly regioselective direct C2-acylation of N-pyrimidine protected indoles with aldehydes is reported at room temperature through the merger of visible light photoredox and palladium(ii) catalysis. Late-stage acylation of tryptophan, selective mono-acylation of carbazole and the syntheses of tubulin inhibitors D-64131 and D-68144 are also demonstrated.

Palladium-catalyzed C2-acylation of indoles with α-diketones assisted by the removable N-(2-pyrimidyl) group

An effective and practical palladium-catalyzed C2-acylation method was successfully developed for the synthesis of 2-acylindoles. A variety of 2-acylindoles were readily prepared from N-pyrimidyl indoles in moderate to good yields. This methodology offers

Synthesis of 2-Acylated Indoles through Palladium-Catalyzed Dehydrogenative Coupling of N -Pyrimidine-Protected Indoles with Aldehydes and Ethyl Glyoxylate

C2-Acylated indoles have been synthesized in good yields through palladium-catalyzed dehydrogenative coupling of N-pyrimidine-protected indoles using aldehydes as the source of acyl reagent and tert-butyl hydroperoxide as the oxidant. 2-Indole carboxylate

Palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids

A palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids was achieved. This protocol represents a novel and complementary approach to 2-aroylindoles. The Royal Society of Chemistry 2013.