1427669-88-2Relevant academic research and scientific papers
Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C-H activation
Zhao, Yaping,Sharma, Upendra K.,Schr?der, Felix,Sharma, Nandini,Song, Gonghua,Van Der Eycken, Erik V.
, p. 32559 - 32563 (2017/07/07)
A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as addit
Dual visible-light photoredox and palladium(II) catalysis for dehydrogenative C2-acylation of indoles at room temperature
Manna, Manash Kumar,Bairy, Gurupada,Jana, Ranjan
supporting information, p. 5899 - 5903 (2017/07/25)
A highly regioselective direct C2-acylation of N-pyrimidine protected indoles with aldehydes is reported at room temperature through the merger of visible light photoredox and palladium(ii) catalysis. Late-stage acylation of tryptophan, selective mono-acylation of carbazole and the syntheses of tubulin inhibitors D-64131 and D-68144 are also demonstrated.
Merger of Visible-Light Photoredox Catalysis and C-H Activation for the Room-Temperature C-2 Acylation of Indoles in Batch and Flow
Sharma, Upendra K.,Gemoets, Hannes P. L.,Schr?der, Felix,No?l, Timothy,Van Der Eycken, Erik V.
, p. 3818 - 3823 (2017/06/19)
A mild and versatile protocol for the C-H acylation of indoles via dual photoredox/transition-metal catalysis was established in batch and flow. The C-H bond functionalization occurred selectively at the C-2 position of N-pyrimidylindoles. This room-temperature protocol tolerated a wide range of functional groups and allowed for the synthesis of a diverse set of acylated indoles. Various aromatic as well as aliphatic aldehydes (both primary and secondary) reacted successfully. Interestingly, significant acceleration (20 to 2 h) and higher yields were obtained under micro flow conditions.
Palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids
Pan, Changduo,Jin, Hongming,Liu, Xu,Cheng, Yixiang,Zhu, Chengjian
supporting information, p. 2933 - 2935 (2013/04/24)
A palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids was achieved. This protocol represents a novel and complementary approach to 2-aroylindoles. The Royal Society of Chemistry 2013.
