1427669-95-1

Upstream product

• 1310708-89-4 3-methyl-1-(pyrimidin-2-yl)-1H-indole 
• 611-73-4 Benzoylformic acid 
• 100-52-7 benzaldehyde 
• 108-88-3 toluene 

Relevant academic research and scientific papers

Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C-H activation

A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as addit

Dual visible-light photoredox and palladium(II) catalysis for dehydrogenative C2-acylation of indoles at room temperature

A highly regioselective direct C2-acylation of N-pyrimidine protected indoles with aldehydes is reported at room temperature through the merger of visible light photoredox and palladium(ii) catalysis. Late-stage acylation of tryptophan, selective mono-acylation of carbazole and the syntheses of tubulin inhibitors D-64131 and D-68144 are also demonstrated.

Synthesis of 2-Acylated Indoles through Palladium-Catalyzed Dehydrogenative Coupling of N -Pyrimidine-Protected Indoles with Aldehydes and Ethyl Glyoxylate

C2-Acylated indoles have been synthesized in good yields through palladium-catalyzed dehydrogenative coupling of N-pyrimidine-protected indoles using aldehydes as the source of acyl reagent and tert-butyl hydroperoxide as the oxidant. 2-Indole carboxylate

Palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids

A palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids was achieved. This protocol represents a novel and complementary approach to 2-aroylindoles. The Royal Society of Chemistry 2013.