1427669-98-4Relevant academic research and scientific papers
Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C-H activation
Zhao, Yaping,Sharma, Upendra K.,Schr?der, Felix,Sharma, Nandini,Song, Gonghua,Van Der Eycken, Erik V.
, p. 32559 - 32563 (2017/07/07)
A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as addit
Dual visible-light photoredox and palladium(II) catalysis for dehydrogenative C2-acylation of indoles at room temperature
Manna, Manash Kumar,Bairy, Gurupada,Jana, Ranjan
supporting information, p. 5899 - 5903 (2017/07/25)
A highly regioselective direct C2-acylation of N-pyrimidine protected indoles with aldehydes is reported at room temperature through the merger of visible light photoredox and palladium(ii) catalysis. Late-stage acylation of tryptophan, selective mono-acylation of carbazole and the syntheses of tubulin inhibitors D-64131 and D-68144 are also demonstrated.
Palladium-catalyzed C2-acylation of indoles with α-diketones assisted by the removable N-(2-pyrimidyl) group
Li, Chunpu,Zhu, Wei,Shu, Shuangjie,Wu, Xiaoming,Liu, Hong
, p. 3743 - 3750 (2015/06/16)
An effective and practical palladium-catalyzed C2-acylation method was successfully developed for the synthesis of 2-acylindoles. A variety of 2-acylindoles were readily prepared from N-pyrimidyl indoles in moderate to good yields. This methodology offers
Pd-catalyzed direct C2-acylation and C2,C7-diacylation of indoles: Pyrimidine as an easily removable C-H directing group
Kumar, Govindharaj,Sekar, Govindasamy
, p. 28292 - 28298 (2015/04/14)
Pyrimidine is successfully used as an easily removable C(sp2)-H directing group for the synthesis of 2-acyl indoles and 2,7-diacyl indoles through direct C-H functionalization using a Pd-catalyst from 1-(pyrimidin-2-yl)-1H-indoles and aldehydes. Easy removal of the pyrimidine directing group using EtONa in DMSO provides C2-acyl indoles.
Palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids
Pan, Changduo,Jin, Hongming,Liu, Xu,Cheng, Yixiang,Zhu, Chengjian
supporting information, p. 2933 - 2935 (2013/04/24)
A palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids was achieved. This protocol represents a novel and complementary approach to 2-aroylindoles. The Royal Society of Chemistry 2013.
