1427744-60-2Relevant academic research and scientific papers
OPTICAL AGENTS FOR IMAGING AND VISUALIZATION OF MATRIX METALLOPROTEINASE ENZYMES
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Paragraph 0175, (2013/03/28)
The invention relates generally to optical agents for biomedical applications including imaging, visualization, phototherapy and diagnostic monitoring of cells and tissue expressing MMPs and/or tissues associated with the expression of MMPs. In some embodiments, for example, optical agents of the present invention selectively bind to, or otherwise preferentially associate with, a target tissue expressing one or more MMPs, and function to couple electromagnetic radiation into and/or out of the target tissue, for example via optical absorption, fluorescence, scattering and/or optoacoustic processes.
Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes
Freskos, John N.,Asmelash, Bethel,Gaston, Kimberly R.,Karwa, Amol,Marzan, Tim A.,Nickols, Maureen A.,Rogers, Thomas E.,Schoenstein, Tasha,Sympson, Carolyn J.,Vu, Bich
, p. 5566 - 5570 (2013/10/01)
We describe the synthesis, MMP-2 and 9 potency, and in vitro evaluation of a series of α-sulfone hydroxmate MMP inhibitors conjugated to a series of dyes with different absorption/emission lamina maxima's that can be used to visualize tumors.
