14281-59-5

Basic information

• Product Name: 4-(morpholin-4-yl)-2-phenylquinoline
• Synonyms: 4-(2-phenyl-4-quinolyl)morpholine; 4-(4-Morpholinyl)-2-phenylquinoline
• CAS NO: 14281-59-5
• Molecular Formula: C₁₉H₁₈N₂O
• Molecular Weight: 290.359
• Mol File: 14281-59-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 507.9°C at 760 mmHg
• Flash Point: 260.9°C
• Density: 1.183g/cm³
• Vapor Pressure: 1.96E-10mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 4-(morpholin-4-yl)-2-phenylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(morpholin-4-yl)-2-phenylquinoline(14281-59-5)
• EPA Substance Registry System: 4-(morpholin-4-yl)-2-phenylquinoline(14281-59-5)

Safety Data

• Hazardous Substances Data: 14281-59-5(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 4979-79-7 4-chloro-2-phenylquinoline 
• 98-88-4 benzoyl chloride 
• 52670-38-9 2-ethynylaniline 
• 176214-83-8 o-tosylaminobenzaldehyde morpholinal 
• 6590-65-4 N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide 
• 176214-89-4 4-Methyl-N-[2-(1-morpholin-4-yl-3-phenyl-prop-2-ynyl)-phenyl]-benzenesulfonamide 

Relevant articles and documents

o-Tosylaminobenzaldehyde aminals in the synthesis of 1,3-disubstituted propargylamines, derivatives of 3H-2-vinylidene-3-aminoindoline and quinoline

o-Tosylaminobenzaldehyde aminals react with propargyl alcohol and its phenyl ether on heating in acetonitrile in the presence of CuI to yield 3H-2-vinylidene-3-aminoindoline derivatives.Analogous reactions with phenylacetylene and dimethylethynylcarbinol result in 1,3-disubstituted propargylamines.The possibility of using the latter compounds in synthesis of quinoline derivatives was shown: cyclization of 1-(o-tosylaminophenyl)-1-morpholino-3-phenylprop-2-yne in the presence of H2SO4 and KOH gave 2-phenylquinoline and 2-phenyl-4-morpholinoquinoline, respectively. 3H-2-Phenoxymethylvinylidene-3-morpholinoindoline was studied by X-ray diffraction spectroscopy. - Keywords: o-tosylaminobenzaldehyde; 3H-2-vinylidene-3-aminoindoline derivatives; 1,3-disubstituted propargylamines; quinoline derivatives; X-ray diffraction study.