1428132-94-8

Basic information

• Product Name: C₁₃H₁₀ClN₃O₂S
• Synonyms: C₁₃H₁₀ClN₃O₂S
• CAS NO: 1428132-94-8
• Molecular Weight: 307.76
• Mol File: 1428132-94-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₀ClN₃O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₀ClN₃O₂S(1428132-94-8)
• EPA Substance Registry System: C₁₃H₁₀ClN₃O₂S(1428132-94-8)

Safety Data

• Hazardous Substances Data: 1428132-94-8(Hazardous Substances Data)

Upstream product

• 1428132-90-4 3-[(4-chlorophenyl)amino]-5-nitrobenzo[d]isothiazole 1,1-dioxide 
• 92083-84-6 3-chloro-5-nitro-1,2-benzothiazole-1,1-dioxide 
• 22952-20-1 5-nitro-1,1-dioxo-1,2-benzothiazol-3-one 
• 22952-19-8 2-methyl-4-nitrobenzenesulfonamide 
• 21320-90-1 5-nitro-2-toluenesulfonyl chloride 
• 99-52-5 2-methyl-4-nitro-benzenamine 

Downstream Products

• 1428132-98-2 C₂₁H₂₀ClN₃O₆S 

Relevant articles and documents

Structure-based design and synthesis of novel pseudosaccharine derivatives as antiproliferative agents and kinase inhibitors

This study is concerned with the implementation of structure-based techniques for the design of new heterocyclic compounds based on pseudosaccharine scaffold with protein kinase inhibition activity. This nucleus was exploited based on the well-known quinazoline core and its interactions with several protein kinases. Two series of compounds employing this new scaffold were synthesized and evaluated at enzymatic and cellular levels. Compound 9b displayed broad spectrum antiproliferative activity on NCI 60-cell lines panel with mean GI50 of 5.4 μM. Investigation of the molecular mechanism showed probable inhibitory activity against Src kinase.