21320-90-1

Basic information

• Product Name: 5-nitrotoluene-2-sulphonyl chloride
• Synonyms: 5-nitrotoluene-2-sulphonyl chloride
• CAS NO: 21320-90-1
• Molecular Formula: C₇H₆ClNO₄S
• Molecular Weight: 235.64484
• EINECS: 244-332-6
• Mol File: 21320-90-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 370.3°Cat760mmHg
• Flash Point: 177.8°C
• Appearance: /
• Density: 1.528g/cm³
• Vapor Pressure: 2.38E-05mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 5-nitrotoluene-2-sulphonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-nitrotoluene-2-sulphonyl chloride(21320-90-1)
• EPA Substance Registry System: 5-nitrotoluene-2-sulphonyl chloride(21320-90-1)

Safety Data

• Hazardous Substances Data: 21320-90-1(Hazardous Substances Data)

Usage

General Description

5-Nitrotoluene-2-sulphonyl chloride is a chemical compound that is often used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is a sulfonyl chloride derivative of 5-nitrotoluene, with a molecular formula of C7H6ClNO4S. 5-Nitrotoluene-2-sulphonyl chloride is a powerful acylating agent and is commonly used in organic synthesis as a reagent for the introduction of the nitro functional group. It is also considered to be a potential mutagen and irritant, so proper precautions should be taken when handling and using this chemical.

InChI:InChI=1/C7H6ClNO4S/c1-5-4-6(9(10)11)2-3-7(5)14(8,12)13/h2-4H,1H3

Upstream product

• 35505-96-5 bis-(2-methyl-4-nitro-phenyl)-disulfide 
• 99-52-5 2-methyl-4-nitro-benzenamine 
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• 7434-70-0 2-methyl-4-nitrobenzenesulfonic acid 
• 13290-74-9 1-chloro-2-methyl-4-nitrobenzene 

Downstream Products

• 7434-70-0 2-methyl-4-nitrobenzenesulfonic acid 
• 106840-80-6 N,2-dimethyl-4-nitrobenzenesulfonamide 
• 1224595-65-6 1-methyl-2-(2-methyl-4-nitrophenyl)-1H-pyrrole 
• 1428132-95-9 C₁₃H₉Cl₂N₃O₂S 
• 1428132-88-0 5-nitro-3-(p-tolylamino)benzo[d]isothiazole 1,1-dioxide 
• 1428132-94-8 C₁₃H₁₀ClN₃O₂S 
• 1428132-93-7 C₁₃H₁₀BrN₃O₂S 
• 1428132-92-6 C₁₄H₁₃N₃O₂S 
• 22952-20-1 5-nitro-1,1-dioxo-1,2-benzothiazol-3-one 
• 22952-19-8 2-methyl-4-nitrobenzenesulfonamide 
• 1428133-01-0 C₂₀H₁₃Cl₃N₄O₃S 
• 1428133-00-9 C₂₀H₁₄Cl₂N₄O₃S 

Relevant articles and documents

OXIDIZED GLUTATHIONE ASSAY

The present invention provides an assay for detection of oxidized glutathione (GSSG).

Structure-based design and synthesis of novel pseudosaccharine derivatives as antiproliferative agents and kinase inhibitors

This study is concerned with the implementation of structure-based techniques for the design of new heterocyclic compounds based on pseudosaccharine scaffold with protein kinase inhibition activity. This nucleus was exploited based on the well-known quinazoline core and its interactions with several protein kinases. Two series of compounds employing this new scaffold were synthesized and evaluated at enzymatic and cellular levels. Compound 9b displayed broad spectrum antiproliferative activity on NCI 60-cell lines panel with mean GI50 of 5.4 μM. Investigation of the molecular mechanism showed probable inhibitory activity against Src kinase.

Studies in the field of diuretic agents. V. A new route to disulphamyl derivatives of benzene.

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