1428183-86-1

Basic information

• Product Name: C₂₀H₁₇F₃N₂O₃S
• Synonyms: C₂₀H₁₇F₃N₂O₃S
• CAS NO: 1428183-86-1
• Molecular Weight: 422.428
• Mol File: 1428183-86-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₇F₃N₂O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₇F₃N₂O₃S(1428183-86-1)
• EPA Substance Registry System: C₂₀H₁₇F₃N₂O₃S(1428183-86-1)

Safety Data

• Hazardous Substances Data: 1428183-86-1(Hazardous Substances Data)

Upstream product

• 317318-96-0 [4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol 
• 175277-03-9 4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester 
• 78120-39-5 (E)-ethyl 3-amino-2-(2-chloroacetyl)but-2-enoate 
• 626-34-6 ethyl aminocrotonate 
• 72505-21-6 4-trifluoromethylbenzthioamide 
• 438577-61-8 4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde 
• 65713-63-5 ethyl 5-methyl-3-oxo-1,2-dihydropyrrole-4-carboxylate 

Relevant articles and documents

Discovery and structure-activity relationships of pyrrolone antimalarials

In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced compound libraries was undertaken by the World Health Organisation Programme for Research and Training in Tropical Diseases (WHO-TDR). We report here the detailed characterization of one of the hits from this process, TDR32750 (8a), which showed potent activity against Plasmodium falciparum K1 (EC50 ～ 9 nM), good selectivity (>2000-fold) compared to a mammalian cell line (L6), and significant activity against a rodent model of malaria when administered intraperitoneally. Structure-activity relationship studies have indicated ways in which the molecule could be optimized. This compound represents an exciting start point for a drug discovery program for the development of a novel antimalarial.