1428228-23-2

Upstream product

• 1428228-07-2 (1R,3aR,5S,7aR)-5-azido-1-((R)-1,5-dimethylhexyl)-3a,7a-dimethyloctahydroinden-4-one 
• 1428228-08-3 (1R,3aR,4R,5S,7aR)-5-amino-1-((R)-1,5-dimethylhexyl)-3a,7a-dimethyloctahydroinden-4-ol 
• 123-11-5 4-methoxy-benzaldehyde 
• 66251-18-1 Grundmann's ketone 
• 1428227-90-0 C₂₂H₄₂OSi 
• 162460-28-8 (1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-3a,7a-dimethyloctahydroinden-4-one 
• 93895-18-2 [(1R,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-4-yloxy]-trimethylsilane 
• 1428227-91-1 [(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-3a,7a-dimethyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yloxy]-trimethylsilane 
• 1428227-92-2 (1R,3aR,5R,7aR)-5-bromo-1-((R)-1,5-di-methylhexyl)-3a,7a-dimethyloctahydroinden-4-one 

Relevant academic research and scientific papers

Stereoselective synthesis of a new class of potent and selective inhibitors of human Δ8,7-sterol isomerase

Starting from Grundmann′s ketone a new chemotype of inhibitors of the post-squalene part of cholesterol biosynthesis was developed. Stereoselective introduction of an angular methyl group at C-3a, followed by a plethora of functionalisations at C-4 and C-5 led to cis-configured amino alcohols as a new chemotype of inhibitors of cholesterol biosynthesis. In cell-based screening systems these compounds were identified to be selective inhibitors of human Δ8,7-sterol isomerase, inhibiting total cholesterol biosynthesis with IC50 values in the low nanomolar range. The most active compounds did not affect fungal Δ8,7-sterol isomerase (in ergosterol biosynthesis), neither showed noteworthy antimicrobial and cytotoxic effects.