1428264-20-3Relevant academic research and scientific papers
Novel imidazophenoxazine-4-sulfonamides: Their synthesis and evaluation as potential inhibitors of PDE4
Reddy, Seelam Venkata,Rao, Gangula Mohan,Kumar, Baru Vijaya,Meda, Chandana L.T.,Deora, Girdhar Singh,Kumar, K. Shiva,Parsa, Kishore V.L.,Pal, Manojit
, p. 1952 - 1963 (2013/04/24)
A number of novel imidazophenoxazine-4-sulfonamides have been designed as potential inhibitors of PDE4. All these compounds were readily prepared via an elegant multi-step method involving the initial construction of 1-nitro-10H-phenoxazine ring and then fused imidazole ring as key steps. Some of these compounds showed promising PDE4B and D inhibition when tested in vitro and good interactions with these proteins in silico. Three of these compounds showed dose dependent inhibition of PDE4B with IC50 value of 3.31 ± 0.62, 1.23 ± 0.18 and 0.53 ± 0.18 μM.
