14283-35-3 Usage
Uses
Used in Organic Synthesis:
Trimethylsilylmethylisocyanate is used as a reagent for the preparation of carboxamides and ureas. Its high reactivity allows it to undergo various reactions, such as addition to aldehydes and ketones to form carbamates, and addition to amines to form ureas. This makes it a valuable tool in the field of organic chemistry for creating a range of chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Trimethylsilylmethylisocyanate is used as an intermediate in the synthesis of various drug molecules. Its ability to form carbamates and ureas makes it a useful building block for the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Chemical Research:
Trimethylsilylmethylisocyanate is also used in chemical research as a versatile reagent for exploring new reaction pathways and developing innovative synthetic methods. Its reactivity and ability to form a variety of products make it an important tool for advancing the understanding of organic chemistry and discovering new chemical reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 14283-35-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,2,8 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 14283-35:
(7*1)+(6*4)+(5*2)+(4*8)+(3*3)+(2*3)+(1*5)=93
93 % 10 = 3
So 14283-35-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H11NOSi/c1-8(2,3)5-6-4-7/h5H2,1-3H3
14283-35-3Relevant academic research and scientific papers
Antitumour imidazotetrazines. Part 33. New synthesis of the antitumour drug temozolomide using 'masked' methyl isocyanates
Wang, Yongfeng,Stevens, Malcolm F. G.,Thomson, William T.,Shutts, Bruce P.
, p. 2783 - 2789 (2007/10/02)
Ethyl 8-carbamoyl-4-oxo-3,4-dihydroimidazo-1,2,3,5-tetrazin-3-ylacetate 6a can be prepared by treating 5-diazoimidazole-4-carboxamide 3 with ethyl isocyanatoacetate or by diazotisation of N-(5-amino-4-carbamoylimidazol-1-ylcarbonyl)glycine ethyl ester 5.Barton radical decarboxylation of the tetrazin-3-ylacetic acid 6b affords temozolomide 1 (26percent) whereas deprotection of the 3-trimethylsilylmethylimidazotetrazine 6g with TBAF in acetonitrile-acetic acid yields 1 in 78percent yield. 3-Benzylimidazotetrazinones 10a-c are stable to hydrogenolytic or oxidative debenzylation reactions.
One-Pot Synthesis of N-((Trimethylsilyl)methyl)imines and (Trimethylsilyl)methyl-Substituted Heterocumulenes from (Trimethylsilyl)methyl Azide
Tsuge, Otohiko,Kanemasa, Shuji,Matsuda, Koyo
, p. 2688 - 2691 (2007/10/02)
The reactions of ((trimethylsilyl)methyl)iminotriphenylphosphorane, prepared in situ from (trimethylsilyl)methyl azide and triphenylphosphine, with carbonyl compounds and with heterocumulenes such as carbon dioxide, carbon disulfide, isocyanates, isothiocyanates, and a ketene provide convenient one-pot syntheses of the corresponding N-((trimethylsilyl)methyl)imines and (trimethylsilyl)methyl-substituted heterocumulenes, which are versatile reagents for the synthesis of heterocyclic compounds.
