1428305-85-4

Basic information

• Product Name: (S)-methyl 4-(4-(4-(4-(4-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yl)oxy)butanamido)phenyl)-1-methyl-1H-pyrrole-2-carboxamido)phenyl)-1-methyl-1H-pyrrole-2-carboxylate
• CAS NO: 1428305-85-4
• Molecular Weight: 742.831
• Mol File: 1428305-85-4.mol

Chemical Properties

• CAS DataBase Reference: (S)-methyl 4-(4-(4-(4-(4-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yl)oxy)butanamido)phenyl)-1-methyl-1H-pyrrole-2-carboxamido)phenyl)-1-methyl-1H-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 4-(4-(4-(4-(4-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yl)oxy)butanamido)phenyl)-1-methyl-1H-pyrrole-2-carboxamido)phenyl)-1-methyl-1H-pyrrole-2-carboxylate(1428305-85-4)
• EPA Substance Registry System: (S)-methyl 4-(4-(4-(4-(4-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yl)oxy)butanamido)phenyl)-1-methyl-1H-pyrrole-2-carboxamido)phenyl)-1-methyl-1H-pyrrole-2-carboxylate(1428305-85-4)

Safety Data

• Hazardous Substances Data: 1428305-85-4(Hazardous Substances Data)

Upstream product

• 349536-24-9 4-[(3'-methoxycarbonylpropyl)oxy]-3-methoxy-2-nitrobenzoic acid 
• 176375-42-1 4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid methyl ester 
• 121-33-5 vanillin 
• 176375-41-0 4-(4-formyl-2-methoxyphenoxy)butanoic acid methyl ester 
• 1314533-98-6 4-(((11aS)-10-((allyloxy)carbonyl)-7-methoxy-5-oxo-11-((tetrahydro-2H- pyran-2-yl)oxy)-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4] diazepin-8-yl)oxy)butanoic acid 
• 1428305-95-6 methyl 4-(4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)phenyl)-1-methyl-1H-pyrrole-2-carboxylate 
• 864076-04-0 methyl 4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxylate 
• 864076-03-9 4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid 
• 864076-02-8 methyl 4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylate 
• 1196-90-3 4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 184643-69-4 1-(4-bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trichloroethan-1-one 
• 21898-65-7 1-methyl-2-trichloroacetyl-1H-pyrrole 
• 864672-97-9 (11S,11aS)-11-hydroxy-7-methoxy-8-(3-methoxycarbonylpropoxy)-5-oxo-2,3,11,11a-tetrahydro-1H,5H-pyrrolo[2,1-c][1,4]benzodiazepine-10-carboxylic acid allyl ester 
• 909415-16-3 4-[5-allyloxycarbonylamino-4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxyphenoxy]butanoic acid methyl ester 

Relevant articles and documents

PYRROLOBENZODIAZEPINES

Pyrrolobenzodiazepine (PBDs) having a (1-methyl-1H-pyrrol-3- yl)phenyl based amino residue were found to be highly effective compounds having improved cytotoxicity ad DNA binding properties.

GC-Targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models

DNA binding 4-(1-methyl-1H-pyrrol-3-yl)benzenamine (MPB) building blocks have been developed that span two DNA base pairs with a strong preference for GC-rich DNA. They have been conjugated to a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) molecule to produce