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Upstream product

• 13610-49-6 2-[2-oxo-benzo[d]oxazole-3(2H)-yl]acetic acid 
• 95-55-6 2-amino-phenol 
• 13610-51-0 ethyl (2‐benzoxazolinone‐3‐yl)acetate 
• 59-49-4 2-Benzoxazolinone 

Relevant academic research and scientific papers

Synthesis and in silico studies of Novel Ru(II) complexes of Schiff base derivatives of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl)methyl]-2(3H)-benzoxazolone compounds as potent Glutathione S-transferase and Cholinesterases Inhibitor

Novel Ru(II) complexes of Shiff base derivatives of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl)methyl]-2(3H)-benzoxazolone were synthesized. The ligands (1a-e) were confirmed by IR, 1H NMR, and 13C NMR spectra (only 1b and 1c). Structures of the synthesized Ru(II) complexes (2a-e) were illuminated by elemental analysis, IR, 1H NMR, 13C NMR, and mass spectra. As the biological studies, the inhibitory potency of the ligands and the novel synthesized complexes were evaluated against the glutathione S-transferase (GST), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes in vitro conditions. Ki values in the range of 26.87-47.63 μM for AChE, 23.51-42.81 μM for BChE, and 33.14-51.73 μM for GST, respectively. The free binding energy of most active inhibitors against AChE, BChE, and GST enzymes were detected as -10.183 kcal/mol, -9.111 kcal/mol, and -6.097 kcal/mol, respectively. All compounds docked were observed to bind in the active site of the enzymes with similar binding orientation and binding interactions with the surrounding amino acids.

Schiff bases of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl) methyl]-2(3H)-benzoxazolone derivatives: Synthesis and biological activity

New Schiff base derivatives of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl) methyl]-2(3H)-benzoxazolone with aromatic aldehydes have been synthesized under microwave irradiation. Structures of the synthesized compounds were confirmed by IR, 1H-NMR and elemental analysis. Variable, but modest antimicrobial and antitubercular activity against the investigated strains of bacteria and fungi were observed. Among the derivatives obtained, 4-bromophenylmethylidene derivative 5j revealed significant antibacterial activity against P. aeruginosa.