1428655-46-2Relevant academic research and scientific papers
Synthesis and cytotoxicity evaluation of oleanolic acid derivatives
Hao, Jia,Liu, Jun,Wen, Xiaoan,Sun, Hongbin
, p. 2074 - 2077 (2013/04/23)
Twelve derivatives of oleanolic acid (1) have been synthesized and evaluated for their inhibitory activities against the growth of prostate PC3, breast MCF-7, lung A549, and gastric BGC-823 cancer cells by MTT assays. Within these series of derivatives, compound 17 exhibited the most potent cytotoxicity against PC3 cell line (IC50 = 0.39 μM) and compound 28 displayed the best activity against A549 cell line (IC50 = 0.22 μM). SAR analysis indicates that H-donor substitution at C-3 position of oleanolic acid may be advantageous for improvement of cytotoxicity against PC3, A549 and MCF-7 cell lines.
