1428798-11-1Relevant articles and documents
Strategies to reduce hERG K+ channel blockade. Exploring heteroaromaticity and rigidity in novel pyridine analogues of dofetilide
Carvalho, Jo?o F. S.,Louvel, Julien,Doornbos, Maarten L. J.,Klaasse, Elisabeth,Yu, Zhiyi,Brussee, Johannes,Ijzerman, Adriaan P.
supporting information, p. 2828 - 2840 (2013/05/22)
Drug-induced blockade of the human ether-a-go-go-related gene K+ channel (hERG) represents one of the major antitarget concerns in pharmaceutical industry. SAR studies of this ion channel have shed light on the structural requirements for hERG