5651-90-1

Usage

Uses

Used in Fragrance Industry:
1-methyl-4-prop-2-ynoxy-benzene is utilized as a key ingredient in the production of fragrances due to its distinctive, slightly fruity scent. Its unique aroma profile makes it a valuable component in creating various fragrance blends for perfumes, colognes, and other scented products.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 1-methyl-4-prop-2-ynoxy-benzene serves as a crucial precursor in the synthesis of various medicinal compounds. Its chemical structure allows for the development of new drugs and the enhancement of existing pharmaceutical formulations.
Used in Organic Synthesis:
As a precursor in organic synthesis, 1-methyl-4-prop-2-ynoxy-benzene is instrumental in the creation of a broad spectrum of organic compounds. Its role in this process is vital for the advancement of chemical research and the development of new materials and substances.
Used in Food Industry:
1-methyl-4-prop-2-ynoxy-benzene is employed as a flavoring agent in the food industry, where it imparts a subtle fruity flavor to various food products. Its use in this capacity contributes to the enhancement of taste profiles and the creation of unique food items.
Safety Note:
It is important to handle 1-methyl-4-prop-2-ynoxy-benzene with care, as it is a flammable substance. Proper storage and handling procedures must be followed to ensure safety in all applications.

InChI:InChI=1/C10H10O/c1-3-8-11-10-6-4-9(2)5-7-10/h1,4-7H,8H2,2H3

Upstream product

• 106-44-5 p-cresol 
• 624-65-7 2-propynyl chloride 
• 106-96-7 propargyl bromide 
• 13662-00-5 p-tolyloxy-acetone semicarbazone 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 2003-82-9 3-bromo-2-propyne 
• 108-95-2 phenol 
• 107-19-7 propargyl alcohol 
• 53299-56-2 4-methyl-1-(2-chloro-2-propenoxy)benzene 
• 85143-27-7 4-p-tolyloxymethyl-1,2,3-selenadiazole 

Downstream Products

• 6698-70-0 (4-methylphenoxy)propan-2-one 
• 139370-98-2 3-(p-tolyloxy)-2-phenylsulfinyl-1-propene 
• 18385-83-6 6-methyl-2H-chromene 
• 115997-62-1 1-(3-Bromo-prop-2-ynyloxy)-4-methyl-benzene 
• 115997-63-2 1-((3-bromoprop-2-yn-1-yl)oxy)-4-methoxybenzene 
• 117543-23-4 1-(3-Chloro-prop-2-ynyloxy)-4-methyl-benzene 
• 91470-78-9 1,4,5,8-Tetrakis<(p-tolyloxy)methyl>-1,3,5,7-cyclooctatetraene 
• 1144040-21-0 1-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-(p-tolyloxymethyl)-1H-[1,2,3]triazole 
• 1266365-90-5 1-phenyl-4-(p-tolyloxy)but-2-yn-1-ol 
• 1266366-33-9 3,4-diiodo-7-methyl-5-phenyl-2,5-dihydrobenzo[b]oxepine 
• 1363250-76-3 3,3'-bis-(4-chlorobenzyl)-5,5'-bis-(p-tolyloxy)methyl-3H,3'H-[4,4']bi[[1,2,3]triazolyl] 
• 1363250-71-8 1-(3-chlorobenzyl)-4-((p-tolyloxy)methyl)-1H-1,2,3-triazole 
• 1313994-69-2 4-((p-tolyloxy)methyl-1-benzyl-1H-1,2,3-triazole) 
• 1313994-72-7 3,3′-dibenzyl-5,5′-bis-p-tolyloxymethyl-3H,3′H-[4,4′]bi[[1,2,3]triazolyl] 

Relevant academic research and scientific papers

Synthesis of sorafenib analogues incorporating a 1,2,3-triazole ring and cytotoxicity towards hepatocellular carcinoma cell lines

A series of 1,2,3-triazole-containing Sorafenib analogues, in which the aryl urea moiety of Sorafenib (1) was replaced with a 1,2,3-triazole ring linking a substituted phenoxy fragment, were prepared successfully via Huisgen 1,3-dipolar cycloaddition and

Preparation method and application of propyne aryl ether compound

The invention particularly relates to a method for preparing propyne aryl ether compounds from aryl phenol, halogenated propyne and derivatives of the halogenated propyne, and belongs to the technical field of preparation of the propyne aryl ether compoun

Compound of dipyrrolopyridine structure Preparation method and medical application

The invention discloses a compound with a dipyrrolo-pyridine structure as well as a preparation method and medical application thereof. The compound provided by the invention has obvious inhibitory activity on JAK family proteins, is an effective JAK inhibitor, and has the prospect of being developed into drugs for inhibiting JAK and further treating diseases.

Enantioselective Palladium-Catalyzed Hydrophosphinylation of Allenes with Phosphine Oxides: Access to Chiral Allylic Phosphine Oxides

A Pd-catalyzed hydrophosphinylation of alkyl and aryl-oxyallenes with phosphine oxides has been developed for the efficient and rapid construction of a family of chiral allylic phosphine oxides with a diverse range of functional groups. This methodology was further applied in the facile construction of chiral 2H-chromene and later stage functionalization of cholesterol.

Synthesis, characterization, and antiplasmodial efficacy of sulfonamide-appended [1,2,3]-triazoles

A series of benzenesulfonamide-appended [1,2,3]-triazole hybrids was synthesized by using [3 + 2] cycloaddition of primary, secondary, and tertiary sulfonamide azides with various phenoxymethylacetylenes under click reaction conditions. After structural c

Iron-Mediated Cyclization of 1,3-Diynyl Propargyl Aryl Ethers with Dibutyl Diselenide: Synthesis of Selenophene-Fused Chromenes

The synthesis of selenophene-fused chromene derivatives starting from 1,3-diynyl propargyl aryl ethers is reported herein. The method is based on carbon-carbon, carbon-selenium, selenium-carbon and carbon-selenium bonds formation in a one-pot protocol, using iron(III) chloride and dibutyl diselenide as promoters. The same reaction conditions were applied to propargyl anilines leading to the formation of 1-(butylselanyl)-selenophene quinolines. The results showed that the dilution and temperature of substrate addition had a crucial influence in the products obtained. When the substrates were added at room temperature, in the absence of a solvent, a mixture of products was obtained, whereas the slowly addition (15 min) of starting materials, as a dichloromethane solution, at 0 °C led to the product formation in good yields. The mechanistic study indicates that the cooperative action between iron(III) chloride and dibutyl diselenide was essential to promote the cyclization, whereas separately none of them was effective in promoting the cyclization. We proved the synthetic utility of heterocycles obtained in the Suzuki cross coupling reaction, giving the corresponding cross-coupled products in good yields. In addition, the organoselenium moiety was removed from the structures of products by using n-butyllithium. (Figure presented.).

Synthesis and neuroprotective effects of novel chalcone-triazole hybrids

The development of novel neuroprotective agents is urgently needed for the treatment of neurodegenerative diseases, affecting aging individuals worldwide. In this study, a new set of chalcone-triazole hybrids (6a-g) was synthesized and evaluated for their

Uniform copper nanoparticles as an inexpensive and efficient catalyst for synthesis of novel β-carbonyl-1, 2, 3-triazoles in water medium

Copper nanoparticles as an efficient, inexpensive catalyst were prepared via ball milling for synthesis of β-carbonyl 1, 2, 3-triazoles from azido alcohol by click reaction in water. An extensive range of raw materials such as sodium azide, phenacyl bromi

Preparation of novel 1,2,3-triazole furocoumarin derivatives via click chemistry and their anti-vitiligo activity

The extracts of Psoralea corylifolia?L. were often used for the repigmentation of leukoderma (vitiligo) in traditional Uygur medicine thousands years ago. Nowadays, its active ingredient, furocoumarins, has been clinically applied since it exhibited stron

Synthesis of 3-Organoselenyl-2H-Coumarins from Propargylic Aryl Ethers via Oxidative Radical Cyclization

A metal-free oxidative radical cyclization/selenylation of propargylic aryl ethers with diaryl diselenides was developed. This protocol provided an alternative method to synthesize 3-organoselenyl-2H-coumarins via the formation of C?Se bond, C?C bond, and C=O bond in one step. Moreover, a broad range of functional groups (such as halogen, aldehyde, ketone, cyano, and nitro group) were tolerated. (Figure presented.).