1429184-64-4

Upstream product

• 225668-35-9 2-(4-chlorophenyl)-1-[4-(methylthio)phenyl]-1-ethanone 
• 100-68-5 methyl-phenyl-thioether 
• 1878-66-6 4-chlorophenylacetic Acid 

Downstream Products

• 1429184-77-9 C₁₇H₁₅ClN₂O₄S₂ 
• 1429184-74-6 C₁₈H₁₇ClN₂O₂S₂ 
• 1429184-80-4 C₁₈H₁₇ClN₂O₄S₂ 
• 1429184-65-5 C₁₅H₁₃ClO₂S 
• 1429184-67-7 C₁₆H₁₃ClN₂O₂S₂ 
• 1415020-22-2 C₁₆H₁₃ClN₂S₂ 
• 1455272-71-5 4-(4-methylthiophenyl)-5-(4-chlorophenyl)-2-(benzylthio)-thiazole 
• 1446909-40-5 5-(4-chlorophenyl)-1-methyl-2-(methylthio)-4-(4-(methylthio)phenyl)-1H-imidazole 
• 1446909-34-7 5-(4-chlorophenyl)-1-methyl-4-(4-(methylthio)phenyl)-1H-imidazole-2(3H)-thione 

Relevant academic research and scientific papers

Synthesis, cytotoxic evaluation, and molecular docking study of 4,5-diaryl-thiazole-2-thione analogs of combretastatin A-4 as microtubule-binding agents

A series of combretastatin A-4 analogs in which cis-olefinic bond replaced by thiazole ring were prepared by reaction of α-bromo-1,2-(p-substituted) diaryl-1-ethanones and dithiocarbamate derivatives. The cytotoxicity of these compounds was determined against three cancer cell lines (HT-29), (MCF-7), (AGS) as well as fibroblastic cell line (NIH-3T3) using MTT assay. Inhibition of tubulin polymerization for some potent compounds was evaluated. These biological studies proved that 6j and 6o were the most potent compounds in this series. Furthermore 2-(methylthio)-substituted compounds show moderate or no activity. Docking studies involving 6j and 6o demonstrated that this analogs could be successfully docked in the colchicine binding site of α,β-tubulin.

Synthesis, cyclooxygenase inhibitory effects, and molecular modeling study of 4-aryl-5-(4-(methylsulfonyl)phenyl)-2-alkylthio and -2-alkylsulfonyl-1H- imidazole derivatives

A series of 4-aryl-5-(4-(methylsulfonyl)phenyl)-2-alkylthio and 2-alkylsulfonyl-1H-imidazole derivatives were synthesized. All compounds were tested in human blood assay to determine COX-1 and COX-2 inhibitory potency and selectivity. Among the synthesize

Convenient and regiospecific method for synthesis of 4,5-diaryl-1-methyl-2- (methylthio)-1H-imidazole

A convenient, high-yielding, regiospecific synthesis of 1H-imidazole-2-thiones ring has been developed. In addition, a series of 4,5-diaryl-1-methyl-2-(methylthio)-1H-imidazoles 8 were synthesized and characterized. The structure of regioisomers was confirmed through nuclear Overhauser effect spectroscopy and NMR spectroscopy. Copyright