225668-35-9

Upstream product

• 100-68-5 methyl-phenyl-thioether 
• 25026-34-0 4-chlorophenacetyl chloride 
• 1878-66-6 4-chlorophenylacetic Acid 

Downstream Products

• 404966-42-3 2-(4-chlorophenyl)-1-(4-methanesulfonylphenyl)ethanone 
• 177755-50-9 1-(4-chlorophenyl)-2-[4-(methylthio)phenyl]ethane-1,2-dione 
• 1446909-40-5 5-(4-chlorophenyl)-1-methyl-2-(methylthio)-4-(4-(methylthio)phenyl)-1H-imidazole 
• 1542256-74-5 5-(4-chlorophenyl)-6-(4-(methylsulfonyl) phenyl)-3-(methylthio)-1,2,4-triazine 
• 1542256-64-3 C₁₅H₁₂ClNO₄S 
• 1542256-69-8 C₁₆H₁₂ClN₃O₂S₂ 
• 1455272-71-5 4-(4-methylthiophenyl)-5-(4-chlorophenyl)-2-(benzylthio)-thiazole 
• 1415020-22-2 C₁₆H₁₃ClN₂S₂ 
• 1429184-67-7 C₁₆H₁₃ClN₂O₂S₂ 
• 1429184-65-5 C₁₅H₁₃ClO₂S 
• 1429184-64-4 C₁₅H₁₂BrClOS 
• 1429184-80-4 C₁₈H₁₇ClN₂O₄S₂ 
• 1429184-74-6 C₁₈H₁₇ClN₂O₂S₂ 
• 1429184-77-9 C₁₇H₁₅ClN₂O₄S₂ 

Relevant academic research and scientific papers

Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines

The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT3 human leukemic cancer cell lines. An arachidonic acid induced platelet aggregation effect on washed rat platelets was studied. Compound 17i was found to be the most potent. The antiplatelet properties may be mediated by interference with the arachidonic acid pathway.

Synthesis of novel substituted diaryl-1,4-diazepines

In this paper a convenient route to new 2,3-diaryl-substituted 1,4-diazepines is described through cyclization of ethanedione derivatives and 1,3-propanediamine. The ethanedione derivatives required were synthesized by microwave-assisted oxidation from ethanones.

Syntheses of 4,5-diaryl-1,2,3-thiadiazoles

Reaction of thionyl chloride with semicarbazones of 1-(4- methylsulfonylphenyl)-2-(4-substituted pheny)lethanone gave 4-(4- methylsulfonylphenyl)-5-(4-substituted) pheny-1,2,3-thiadiazoles 5. Compounds 5-phenyl-4-(substitutedphenyl)-1,2,3-thiadiazoles 14 were similarly prepared. Chlorosulfonation of the latter followed by ammonia gave the desired compounds 5-(4-aminosulfonylphenyl)-4-(substituted) phenyl-1,2,3-thiadiazoles 6. Copyright Taylor & Francis Inc.

Synthesis and biological evaluation of 2-phenylpyran-4-ones: A new class of orally active cyclooxygenase-2 inhibitors

A series of 2-phenylpyran-4-ones were prepared and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2). Extensive structure-activity relationship work was carried out within this series, and a number of potent and selective COX-2 inhibitors were identified. Compounds having a p-methylsulfone group at the 2-phenyl ring showed the best COX-2 inhibitory activity. The introduction of a substituted phenoxy ring at position 3 enhanced both the in vitro and in vivo activity within the series. A selected group of 3-phenoxypyran-4-ones exhibited excellent activity in an experimental model of pyresis. The in vivo antiinflammatory activity of these compounds was confirmed with the evaluation of their antiarthritic and analgesic effectiveness. Moreover, their pharmacokinetic profile in rats is compatible with a once a day administration by oral route in humans. Within this novel series, compounds 21, 31, 34, and 35 have been selected for further preclinical and clinical evaluation.