1429256-80-3

Upstream product

• 1423027-23-9 ethyl 3-[(3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino]-2,2-difluoropropanoate 
• 1423027-26-2 ethyl 5,5-difluoro-1-(4-methoxybenzyl)-4-oxopiperidine-3-carboxylate 
• 1423027-29-5 1-(4-methoxybenzyl)-3,3-difluoropiperidin-4-one 
• 1215071-17-2 tert-butyl 3,3-difluoro-4-oxo-piperidine-1-carboxylate 
• 53848-17-2 2-bromo-6-methylaniline 

Relevant academic research and scientific papers

Novel synthesis of 4,4-difluoropyrido[4,3-b]indoles via intramolecular Heck reaction

Various difluoropyridoindoles were synthesized via a palladium-catalyzed intramolecular Heck reaction as a key step. Thus, ortho-bromoanilines and difluoropiperidinone were treated with (PPh3)2PdCl 2 and base in pyridine to give the regioselective cyclized heterocycles in modest to satisfactory yields. Copyright