142929-48-4

Basic information

• Product Name: 4-MORPHOLINECARBOXYLIC ACID, 3-OXO-, 1,1-DIMETHYLETHYL ESTER
• Synonyms: 4-MORPHOLINECARBOXYLIC ACID, 3-OXO-, 1,1-DIMETHYLETHYL ESTER;tert-butyl 3-oxomorpholine-4-carboxylate;1,1-Dimethylethyl 3-Oxo-4-Morpholinecarboxylate
• CAS NO: 142929-48-4
• Molecular Formula: C₉H₁₅NO₄
• Molecular Weight: 201.22
• Mol File: 142929-48-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 337.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.168±0.06 g/cm3(Predicted)
• PKA: -2.52±0.20(Predicted)
• CAS DataBase Reference: 4-MORPHOLINECARBOXYLIC ACID, 3-OXO-, 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MORPHOLINECARBOXYLIC ACID, 3-OXO-, 1,1-DIMETHYLETHYL ESTER(142929-48-4)
• EPA Substance Registry System: 4-MORPHOLINECARBOXYLIC ACID, 3-OXO-, 1,1-DIMETHYLETHYL ESTER(142929-48-4)

Safety Data

• Hazardous Substances Data: 142929-48-4(Hazardous Substances Data)

Upstream product

• 109-11-5 morpholine-3-one 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 195964-53-5 tert-butyl 3-methoxymorpholine-4-carboxylate 
• 1429228-74-9 tert-butyl 5-((diphenoxyphosphoryl)oxy)-2,3-dihydro-4H-1,4-oxazine-4-carboxylate 
• 1429228-76-1 tert-butyl 3-(4-(methoxycarbonyl)phenyl)morpholine-4-carboxylate 
• 1429228-75-0 tert-butyl 5-(4-(methoxycarbonyl)phenyl)-2H-1,4-oxazine-4(3H)-carboxylate 
• 1429228-72-7 tert-butyl (3R)-3-[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromo-pyrazin-2-yl]isoxazol-3-yl]phenyl]morpholine-4-carboxylate 
• 1429228-71-6 tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate 
• 1429228-69-2 tert-butyl (3R)-3-{4-[(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate 
• 1429228-68-1 tert-butyl (3R)-3-(4-formylphenyl)morpholine-4-carboxylate 
• 1429228-67-0 tert-butyl (3R)-3-[4-(hydroxymethyl)phenyl]morpholine-4-carboxylate 
• 1429228-66-9 tert-butyl (3R)-3-(4-methoxycarbonylphenyl)morpholine-4-carboxylate 
• 1335139-79-1 (2Z)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methylene}morpholin-3-one 
• 1359024-28-4 C₃₀H₃₃NO₇ 
• 1359021-86-5 C₃₁H₃₅NO₈ 
• 142929-63-3 2-Benzyl-2-(2-tert-butoxycarbonylamino-ethoxy)-3-phenyl-propionic acid ethyl ester 

Relevant articles and documents

HETEROARYL COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

A Straightforward Synthesis of Six-Membered-Ring Heterocyclic α-Aminophosphonic Acids from N-Acyliminium Ions

A convenient synthesis of phosphonic analogues of pipecolic acid and its heterocyclic analogues is reported. The major step of the elaborated procedure is the introduction of the phosphonate group into the skeleton of the appropriate cyclic amide through N-acyliminium ions. The former ones were obtained by preparation of the hemiaminals or their methyl ethers from the N-protected cyclic amides. Finally, the reaction with trimethyl phosphite in the presence of BF3·OEt2 afforded the desired phosphonates, which were converted into phosphonic acids by the hydrolysis of phosphonate moiety with simultaneous cleavage of the nitrogen protecting groups.

COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE

The invention relates to the compound 5-(4-isopropylsulfonylphenyl) -3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazine-2-amine and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of ATR kinase.